文摘
Purpose The purpose of this study was to determine the intubation time needed to facilitate tracheal intubation (TimeEI) with a low dose of rocuronium (0.3?mg/kg) during propofol induction, and to determine whether this time was reduced by the administration of atropine. Methods Forty-six children, aged 3-0?years, were randomly assigned to receive either saline (control group) or atropine 10?μg/kg (atropine group). Anesthesia was induced with alfentanil 10?μg/kg, propofol 2.5?mg/kg, and rocuronium 0.3?mg/kg. Each TimeEI at which tracheal intubation was attempted was predetermined according to the up-and-down method. The values of TimeEI that provided excellent intubation conditions in 50 and 95?% of patients were defined as TimeEI50 and TimeEI95, respectively. Results TimeEI50?±?SD was 160?±?26.2 and 150?±?13.7?s in the control and atropine groups, respectively. Using isotonic regression, TimeEI95 in the control and atropine groups was 199?s (95?% CI 198.8-00.7?s) and 171?s (95?% CI 171.3-72.1?s), respectively. TimeEI95 was significantly higher in the control group than in the atropine group (P?<?0.001). HR was significantly higher in the atropine group than in the control group during the study period. Conclusions This study demonstrated that the TimeEI95 of a low dose of rocuronium (0.3?mg/kg) required for excellent tracheal intubation was 199?s during i.v. anesthesia induction using propofol and alfentanil in children. Also, i.v. atropine (10?μg/kg) before anesthesia induction was able to reduce TimeEI95 by 28?s.