Platinum nanoparticle-doped multiwalled carbon-nanotube-modified glassy carbon electrode as a sensor for simultaneous determination of atenolol and propranolol in neutral solution

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• 作者：Zhao Kun ; Chen Hongtao ; Yuan Yue ; Bao Zhihong ; Lu Fangzheng ; Li Sanming
• 关键词：Chemically modified electrode ; Platinum nanoparticles ; Multiwalled carbon nanotubes ; Atenolol ; Propranolol
• 刊名：Ionics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：21
• 期：4
• 页码：1129-1140
• 全文大小：1,514 KB
• 参考文献：1. Hardman, JG, Limbird, LE, Gilman, AG (1996) Goodman & Gilman’s—the pharmacological basis of therapeutics. McGraw-Hill, New York
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Electrochemistry
  Materials Science
  Physical Chemistry
  Condensed Matter
  Renewable Energy Sources
  Electrical Power Generation and Transmission
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1862-0760

文摘

In this paper, the simultaneous determination of β-blockers (atenolol (ATN) and propranolol (PRO)) was investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at platinum nanoparticle-doped multiwalled carbon-nanotube-modified glassy carbon electrode (PtNPs/MWCNTs/GCE) in 0.1?M PBS (pH 7.4) solution. The modifier, PtNP-doped MWCNTs (PtNPs/MWCNTs), was characterized by transmission electron microscopy (TEM) and electrochemical method which showed an excellent character for electrocatalytic oxidization of ATN and PRO. In addition, the experimental parameters such as pH values, the concentration of PtNPs/MWCNTs, and the scan rate were optimized. CV and DPV results show that the β-blockers can be detected selectively and sensitively at modified GCE. Under the optimized condition, the detection limits of ATN and PRO are 1.17 and 0.15?μM (S/N--) with the linear ranges of 5.8-16 and 0.2-0?μM, respectively.