Tetracationic compounds based on 1,4-diazabicyclo[2.2.2]octane: antibacterial activity and reactions with N-containing nucleophiles
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- 作者：E. A. Burakova ; I. V. Saranina ; N. V. Tikunova…
- 刊名：Russian Chemical Bulletin
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：64
- 期：6
- 页码：1400-1405
- 全文大小：248 KB
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I. V. Saranina (1)
N. V. Tikunova (1)
V. N. Sil´nikov (1)
1. Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 prosp. Akad. Lavrent´eva, 630090, Novosibirsk, Russian Federation
Chemistry
Organic Chemistry
Inorganic Chemistry
Russian Library of Science
文摘
Antibacterial activity of tetracationic compounds based on 1,4-diazabicyclo[2.2.2]octane (DABCO) bis-quaternary salts with dodecyl substituents bound by linker groups containing four carbon atoms was studied. All the compounds exhibited activity against the test-strains under study. The gram-positive culture S. aureus was found to be the most sensitive to the influence of compounds in question. The highest activity against S. aureus was exhibited by the compounds containing a but-2-yne or a butane linker; their efficiency exceeded that of the reference compound, antibiotic Ciprofloxacin. For the gram-negative culture P. aeruginosa, the highest activity was exhibited by the compound containing a but-2-yne linker. The compounds with a but-2-yne or a butane linker are stable in the presence of nitrogen-containing nucleophiles, which makes them promising for further studies.