Survivin, a target to modulate the radiosensitivity of Ewing’s sarcoma

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• 作者：B. Greve (1) greveb@uni-muenster.de
  F. Sheikh-Mounessi (1)
  B. Kemper (2)
  I. Ernst (1)
  M. G?tte (3)
  H.T. Eich (1)
• 关键词：Survivin – Ewing’s sarcoma – Birc5 – Radiosensitivity – YM155
• 刊名：Strahlentherapie und Onkologie
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：188
• 期：11
• 页码：1038-1047
• 全文大小：1,000.3 KB
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• 作者单位：1. Klinik und Poliklinik für Strahlentherapie -Radioonkologie, Universit?tsklinikum Münster, Albert-Schweitzer Campus 1 Geb?ude A1, 48149 Münster, Germany2. Zentrum für Biomedizinische Optik und Photonik, Universit?tsklinikum Münster, 48149 Münster, Germany3. Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universit?tsklinikum Münster, 48149 Münster, Germany
• ISSN：1439-099X

文摘

Background and purpose Radiotherapy constitutes an essential element in the multimodal therapy of Ewing’s sarcoma. Compared to other sarcomas, Ewing tumors normally show a good response to radiotherapy. However, there are consistently tumors with a radioresistant phenotype, and the underlying mechanisms are not known in detail. Here we investigated the association between survivin protein expression and the radiosensitivity of Ewing’s sarcoma in vitro.