P2X7 receptor of rat dorsal root ganglia is involved in the effect of moxibustion on visceral hyperalgesia
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- 作者：Shuangmei Liu ; Qingming Shi ; Qicheng Zhu ; Ting Zou ; Guilin Li…
- 关键词：Moxibustion ; Dorsal root ganglia ; Purinergic 2X7 receptor ; Satellite glial cell ; Visceral hyperalgesia ; Colorectal distension
- 刊名：Purinergic Signalling
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：11
- 期：2
- 页码：161-169
- 全文大小：1,193 KB
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Qingming Shi (4)
Qicheng Zhu (1)
Ting Zou (1)
Guilin Li (1)
An Huang (5)
Bing Wu (1)
Lichao Peng (1)
Miaomiao Song (1)
Qin Wu (1)
Qiuyu Xie (2)
Weijian Lin (2)
Wei Xie (2)
Shiyao Wen (2)
Zhedong Zhang (2)
Qiulan Lv (1)
Lifang Zou (1)
Xi Zhang (1)
Mofeng Ying (1)
Guodong Li (6)
Shangdong Liang (1) (3)
1. Department of Physiology, Medical School, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China
4. Orthopedics Department of Second Affiliated Hospital, Medical School, Nanchang University, Nanchang, 330006, People’s Republic of China
5. Jiangxi University of Finance and Economics, Nanchang, Jiangxi, 330006, People’s Republic of China
2. 2012 Grade of Department of Clinical Medicine, Nanchang University, Nanchang, 330006, People’s Republic of China
6. Department of Clinical Research, Singapore General Hospital, Singapore, 169856, Singapore
3. Institute of Life Science, Nanchang University, Nanchang, 330006, People’s Republic of China - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine
Pharmacology and Toxicology
Human Physiology
Neurosciences
Cancer Research - 出版者：Springer Netherlands
- ISSN：1573-9546
文摘
Irritable bowel syndrome (IBS) and inflammatory bowel disease often display visceral hypersensitivity. Visceral nociceptors after inflammatory stimulation generate afferent nerve impulses through dorsal root ganglia (DRG) transmitting to the central nervous system. ATP and its activated-purinergic 2X7 (P2X7) receptor play an important role in the transmission of nociceptive signal. Purinergic signaling is involved in the sensory transmission of visceral pain. Moxibustion is a therapy applying ignited mugwort directly or indirectly at acupuncture points or other specific parts of the body to treat diseases. Heat-sensitive acupoints are the corresponding points extremely sensitive to moxa heat in disease conditions. In this study, we aimed to investigate the relationship between the analgesic effect of moxibustion on a heat-sensitive acupoint “Dachangshu-and the expression levels of P2X7 receptor in rat DRG after chronic inflammatory stimulation of colorectal distension. Heat-sensitive moxibustion at Dachangshu acupoint inhibited the nociceptive signal transmission by decreasing the upregulated expression levels of P2X7 mRNA and protein in DRG induced by visceral pain, and reversed the abnormal expression of glial fibrillary acidic protein (GFAP, a marker of satellite glial cells) in DRG. Consequently, abdominal withdrawal reflex (AWR) score in a visceral pain model was reduced, and the pain threshold was elevated. Therefore, heat-sensitive moxibustion at Dachangshu acupoint can produce a therapeutic effect on IBS via inhibiting the nociceptive transmission mediated by upregulated P2X7 receptor.