Neutrophilic dermatoses and autoinflammatory diseases with skin involvement—innate immune disorders

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• 作者：Alexander A. Navarini ; Takashi K. Satoh ; Lars E. French
• 关键词：Skin ; Neutrophil ; Granulocyte ; Autoinflammatory ; IL ; 1 ; Innate immune disorders ; Classification ; Merging ; Pustular
• 刊名：Springer Seminars in Immunopathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：38
• 期：1
• 页码：45-56
• 全文大小：473 KB
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• 作者单位：Alexander A. Navarini (1)
  Takashi K. Satoh (1)
  Lars E. French (1)
  
  1. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1863-2300

文摘

Neutrophilic dermatoses (NDs) such as Sweet’s syndrome and pyoderma gangrenosum were first described more than 50 years ago and grouped based on their clinical features combined with the typical, neutrophil-rich cutaneous inflammation. In contrast, the recently identified autoinflammatory diseases (ADs) that are also associated with neutrophil granulocyte infiltration of the skin were first characterized based on their genetic architecture. Though both the older ND and the newer AD encompass distinct conditions, they can be seen as parts of a spectrum of innate inflammation. Both groups of diseases show so many overlapping clinical, pathogenetic, histologic, and genetic features that together they should likely be considered as innate immune disorders. Keywords Skin Neutrophil Granulocyte Autoinflammatory IL-1 Innate immune disorders Classification Merging Pustular