Epigenetic inactivation of FAT4 contributes to gastric field cancerization

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• 作者：Satoshi Yoshida ; Satoshi Yamashita ; Tohru Niwa ; Akiko Mori ; Seiji Ito…
• 关键词：FAT4 ; DNA methylation ; Gastric cancer ; CpG island methylator phenotype ; Helicobacter pylori
• 刊名：Gastric Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：136-145
• 全文大小：628KB
• 刊物类别：Medicine
• 刊物主题：Surgical Oncology; Oncology; Abdominal Surgery; Gastroenterology; Cancer Research;
• 出版者：Springer Japan
• ISSN：1436-3305
• 卷排序：20

文摘

BackgroundGastric cancer (GC) is highly influenced by aberrant methylation, and accumulation of aberrant methylation in gastric mucosae produces an epigenetic field for cancerization. Nevertheless, the individual driver genes involved in such field cancerization are still unclear. Here, we aimed to demonstrate that FAT4, a novel tumor suppressor identified by exome sequencing of GC, is methylation-silenced and that such methylation is involved in epigenetic field cancerization for GC.