Effect of the saturation pulse duration on chemical exchange saturation transfer in amide proton transfer MR imaging: a phantom study

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• 作者：Tatsuhiro Wada ; Osamu Togao ; Chiaki Tokunaga…
• 关键词：Chemical exchange saturation transfer (CEST) ; Amide proton transfer (APT) imaging ; Parallel RF transmission ; Saturation pulse duration ; Chicken egg white
• 刊名：Radiological Physics and Technology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：9
• 期：1
• 页码：15-21
• 全文大小：907 KB
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• 作者单位：Tatsuhiro Wada (1)
  Osamu Togao (2)
  Chiaki Tokunaga (1)
  Ryouhei Funatsu (1)
  Kouji Kobayashi (1)
  Yasuhiko Nakamura (1)
  
  1. Division of Radiology, Department of Medical Technology, Kyushu University Hospital, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
  2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
  
• 刊物主题：Imaging / Radiology; Nuclear Medicine; Radiotherapy; Medical and Radiation Physics;
• 出版者：Springer Japan
• ISSN：1865-0341

文摘

Amide proton transfer (APT) contrast imaging is based on the chemical exchange saturation transfer (CEST) of protons between the amide groups and bulk water. Here, we demonstrate the effect of the saturation pulse duration on CEST in APT imaging with use of a clinical MR scanner. Four samples were prepared from chicken egg white diluted with H₂O. Experiments were performed on a 3T clinical MR scanner with use of a body coil for two-channel parallel radiofrequency transmission. APT images were acquired at six frequency offsets (± 3.0, ± 3.5, ± 4.0 ppm) with respect to the water resonance as well as one far off-resonant frequency (−160 ppm) for signal normalization. The CEST effect was defined as asymmetry of the magnetization transfer ratio at 3.5 ppm. We measured the CEST effects in the egg white samples with different concentrations at seven saturation pulse durations. The influence of the extension of repetition time (TR) on the CEST effect was also evaluated. The CEST effect was not influenced by the change in TR. The CEST effect was increased significantly with the concentration when the duration was ≥1.0 s (P < 0.01). The CEST effect was highly correlated with the concentration at all saturation pulse durations, and its increase ratio was higher at longer saturation pulse durations. In conclusion, a long saturation pulse duration is useful for the sensitive detection of mobile proteins and peptides in APT imaging. Keywords Chemical exchange saturation transfer (CEST) Amide proton transfer (APT) imaging Parallel RF transmission Saturation pulse duration Chicken egg white