Detailed morphogenetic analysis of the embryonic chicken pars tuberalis as glycoprotein alpha subunit positive region

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• 作者：Makiko Inoue (1)
  Sayaka Aizawa (1)
  Yuriko Higaki (1)
  Akira Kawashima (2)
  Kanako Koike (1)
  Hiroyasu Takagi (1)
  Takafumi Sakai (1)
  Ichiro Sakata (1)
  
• 关键词：Pars tuberalis ; Alpha glycoprotein subunit ; Rathke’s pouch ; Chicken ; Development ; In situ hybridization
• 刊名：Journal of Molecular Histology
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：44
• 期：4
• 页码：401-409
• 全文大小：824KB
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• 作者单位：Makiko Inoue (1)
  Sayaka Aizawa (1)
  Yuriko Higaki (1)
  Akira Kawashima (2)
  Kanako Koike (1)
  Hiroyasu Takagi (1)
  Takafumi Sakai (1)
  Ichiro Sakata (1)
  
  1. Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan
  2. Division of Bioimaging Sciences, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
  

文摘

The pars tuberalis (PT) is a part of the anterior pituitary gland that is located as a thin cell layer surrounding the median eminence. The characteristics of PT, including cell shape and cell composition, differ from those of the pars distalis (PD), suggesting that PT has unique physiological functions and different morphogenesis compared to PD. In this study, we used chicken embryos and showed for the first time that most hormone-producing cells in PT at embryonic day (E) 20.0 were only glycoprotein α subunit (αGSU)-positive staining cells. Then, using serial frontal and sagittal sections, we examined the detailed distribution of the αGSU mRNA-expressing region, as a marker of PT in the chicken embryonic pituitary gland during the E3.0-0.0 period. This three-dimensional expression pattern analysis clarified that αGSU mRNA expression initially appeared only in the bilateral regions of the Rathke’s recess (RR) at E3.5, and this region expanded and showed a ring-like structure on RR. Subsequently, this αGSU mRNA-expressing region gradually expanded upward and reached the diencephalon at E8.0. This region became thinner as it surrounded the base of the diencephalon from E12.0 to E20.0. In this study, we demonstrated the detailed morphological changes of the chicken PT primordium by detecting αGSU mRNA, and we also showed that PT is a unique region in the early developmental stage.