Homéostasie chlorure et cotransporteurs cation-chlorure, douleur et nociception
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- 作者：F. Scamps (1)
S. Pieraut (2)
J. Valmier (3) - 关键词：Douleur ; NKCC1 ; KCC2 ; Homéostasie chlorure ; Ganglions spinaux ; Moelle épinière ; Pain ; NKCC1 ; KCC2 ; Chloride homeostasis ; Dorsal root ganglion ; Spinal cord
- 刊名：Douleur et Analg篓娄sie
- 出版年：2008
- 出版时间：November 2008
- 年：2008
- 卷：21
- 期：4
- 页码：203-208
- 全文大小：234KB
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S. Pieraut (2)
J. Valmier (3)
1. Inserm U583, 80, rue Augustin-Fliche, F-34000, Montpellier, France
2. Université Montpellier-II, 80, rue Augustin-Fliche, F-34000, Montpellier, France
3. Inserm U583, université Montpellier-II, 80, rue Augustin-Fliche, F-34000, Montpellier, France
文摘
By regulating the anionic gradient, two cationchloride cotransporters, NKCC1, which promotes the entrance of chloride ions and KCC2, which promotes their exit, modulate the GABAergic system and control pain mechanisms. Following inflammation or nerve injury, the increase in NKCC1 activity among sensory neurons and/or the decrease in KCC2 expression in spinal neurons, leads to a loss of inhibitory tone and induces neuropathic pain.