Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO
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- 作者：Huey-Jen Tsay ; Yung-Cheng Huang ; Yi-Jen Chen ; Yun-Hao Lee…
- 关键词：Scavenger receptor A ; MARCO ; SRCR domain ; N ; glycosylation ; Alzheimer’s disease ; oligomeric β ; amyloid
- 刊名：Journal of Biomedical Science
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：23
- 期：1
- 全文大小：2,541 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine - 出版者：Springer Netherlands
- ISSN：1423-0127
文摘
Background The accumulation of soluble oligomeric amyloid-β peptide (oAβ) proceeding the formation of senile plaques contributes to synaptic and memory deficits in Alzheimer’s disease. Our previous studies have indentified scavenger receptor A (SR-A), especially SR-A type I (SR-AI), as prominent scavenger receptors on mediating oAβ clearance by microglia while glycan moiety and scavenger receptor cysteine-rich (SRCR) domain may play the critical role. Macrophage receptor with collagenous structure (MARCO), another member of class A superfamily with a highly conserved SRCR domain, may also play the similar role on oAβ internalization. However, the role of N-glycosylation and SRCR domain of SR-AI and MARCO on oAβ internalization remains unclear.