Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives
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- 作者：Robert Gr¨¹tzmann ; Hans Detlev Saeger ; Jutta L¨¹ttges ; Hans Konrad Schackert ; Holger Kalthoff ; G¨¹nter Kl?ppel and Christian Pilarsky
- 关键词：Pancreatic ductal carcinoma ; Microarray ; Gene expression profiling ; Pancreatic cancer
- 刊名：International Journal of Colorectal Disease
- 出版年：2004
- 出版时间：September 2004
- 年：2004
- 卷：19
- 期：5
- 页码：401-413
- 全文大小：277 KB
文摘
Background Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells.