N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer

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• 作者：Steffen Pistorius ; Heike Goergens ; Christoph Engel ; Jens Plaschke ; Stefan Krueger ; Ruth Hoehl ; Hans-Detlev Saeger and Hans K. Schackert
• 关键词：NAT2 ; Sporadic colorectal cancer ; Familial colorectal cancer ; Bethesda criteria ; Microsatellite instability
• 刊名：International Journal of Colorectal Disease
• 出版年：2007
• 出版时间：February, 2007
• 年：2007
• 卷：22
• 期：2
• 页码：137-143
• 全文大小：143 KB

文摘

Introduction N-Acetyltransferase (NAT) 2 is an important enzyme involved in the metabolism of different xenobiotics, including potential carcinogens. Allelic variants of the NAT2 gene are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA) or rapid acetylator (RA) phenotypes and causing the individual differences in the NAT2 metabolic capacity. To clarify the potential modifying role of the NAT2 acetylator status in microsatellite stable (MSS) colorectal cancer (CRC), we studied 140 patients with sporadic CRC (group 1) and 69 patients with CRC who met at least one criterion of the revised Bethesda guidelines (group 2).