HECT E3s and human disease

详细信息    查看全文

• 作者：Martin Scheffner (1)
  Olivier Staub (2)
  
• 刊名：BMC Biochemistry
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：8
• 期：1-supp
• 全文大小：982KB
• 参考文献：1. Huibregtse JM, Scheffner M, Beaudenon S, Howley PM:A family of proteins structurally and functionally related to the E6鈥揂P ubiquitin-protein ligase. / Proc Natl Acad Sci USA 1995,92:2563鈥?567. CrossRef
  2. Scheffner M, Nuber U, Huibregtse JM:Protein ubiquitination involving an E1鈥揈2鈥揈3 enzyme ubiquitin thioester cascade. / Nature 1995,373:81鈥?3. CrossRef
  3. Schwarz SE, Rosa JL, Scheffner M:Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7. / J Biol Chem 1998,273:12148鈥?2154. CrossRef
  4. Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP:Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2鈥揈3 enzyme cascade. / Science 1999,286:1321鈥?326. CrossRef
  5. Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP:Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. / Mol Cell 2003,11:249鈥?59. CrossRef
  6. Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL:Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. / Mol Cell 2005,19:297鈥?08. CrossRef
  7. Pickart CM:Mechanisms underlying ubiquitylation. / Annu Rev Biochem 2001,70:503鈥?33. CrossRef
  8. Glickman MH, Ciechanover A:The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. / Physiol Rev 2002,82:373鈥?28.
  9. Kerscher O, Felberbaum R, Hochstrasser M:Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins. / Annu Rev Cell Dev Biol 2006,22:159鈥?80. CrossRef
  10. Garcia-Gonzalo FR, Rosa JL:The HERC proteins: functional and evolutionary insights. / Cell Mol Life Sci 2005,62:1826鈥?838. CrossRef
  11. Shearwin-Whyatt L, Dalton HE, Foot N, Kumar S:Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. / Bioessays 2006,28:617鈥?28. CrossRef
  12. Ingham RJ, Gish G, Pawson T:The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. / Oncogene 2004,23:1972鈥?984. CrossRef
  13. Bischoff FR, Ponstingl H:Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. / Nature 1991,354:80鈥?2. CrossRef
  14. Renault L, Nassar N, Vetter I, Becker J, Klebe C, Roth M, Wittinghofer A:The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. / Nature 1998,392:97鈥?01. CrossRef
  15. Renault L, Kuhlmann J, Henkel A, Wittinghofer A:Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). / Cell 2001,105:245鈥?55. CrossRef
  16. Nemergut ME, Mizzen CA, Stukenberg T, Allis CD, Macara IG:Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B. / Science 2001,292:1540鈥?543. CrossRef
  17. Staub O, Rotin D:WW domains. / Structure 1996,4:495鈥?99. CrossRef
  18. Sudol M, Hunter T:NeW wrinkles for an old domain. / Cell 2000,103:1001鈥?004. CrossRef
  19. Macias MJ, Wiesner S, Sudol M:WW and SH3 domains, two different scaffolds to recognize proline-rich ligands. / FEBS Lett 2002,513:30鈥?7. CrossRef
  20. Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M:p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. / EMBO J 1996,15:4262鈥?273.
  21. Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL:TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. / J Biol Chem 2006,281:8313鈥?316. CrossRef
  22. Rinchik EM, Carpenter DA, Handel MA:Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene. / Proc Natl Acad Sci USA 1995,92:6394鈥?398. CrossRef
  23. Lehman AL, Nakatsu Y, Ching A, Bronson RT, Oakey RJ, Keiper-Hrynko N, Finger JN, Durham-Pierre D, Horton DB, Newton JM, Lyon MF, Brilliant MH:A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice. / Proc Natl Acad Sci USA 1998,95:9436鈥?441. CrossRef
  24. Amos-Landgraf JM, Ji Y, Gottlieb W, Depinet T, Wandstrat AE, Cassidy SB, Driscoll DJ, Rogan PK, Schwartz S, Nicholls RD:Chromosome breakage in the Prader-Willi and Angelman syndromes involves recombination between large, transcribed repeats at proximal and distal breakpoints. / Am J Hum Genet 1999,65:370鈥?86. CrossRef
  25. Nicholls RD, Knepper JL:Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes. / Annu Rev Genomics Hum Genet 2001,2:153鈥?75. CrossRef
  26. Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M:A novel human gene encoding HECT domain and RCC1鈥搇ike repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. / Biochem Biophys Res Commun 1999,266:115鈥?22. CrossRef
  27. Dastur A, Beaudenon S, Kelley M, Krug RM, Huibregtse JM:Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells. / J Biol Chem 2006,281:4334鈥?338. CrossRef
  28. Wong JJ, Pung YF, Sze NS, Chin KC:HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. / Proc Natl Acad Sci USA 2006,103:10735鈥?0740. CrossRef
  29. Polo S, Sigismund S, Faretta M, Guidi M, Capua MR, Bossi G, Chen H, De Camilli P, Di Fiore PP:A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. / Nature 2002,416:451鈥?55. CrossRef
  30. Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, Rotin D, Staub O:Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. / J Clin Invest 1999,103:667鈥?73. CrossRef
  31. Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X:NEDD4鈥? Is a proto-oncogenic ubiquitin ligase for PTEN. / Cell 2007,128:129鈥?39. CrossRef
  32. Blot V, Perugi F, Gay B, Prevost MC, Briant L, Tangy F, Abriel H, Staub O, Dokhelar MC, Pique C:Nedd4.1鈥搈ediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV鈥? Gag trafficking towards the multivesicular body pathway prior to virus budding. / J Cell Sci 2004,117:2357鈥?367. CrossRef
  33. Fukuchi M, Fukai Y, Masuda N, Miyazaki T, Nakajima M, Sohda M, Manda R, Tsukada K, Kato H, Kuwano H:High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. / Cancer Res 2002,62:7162鈥?165.
  34. Fang D, Elly C, Gao B, Fang N, Altman Y, Joazeiro C, Hunter T, Copeland N, Jenkins N, Liu YC:Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. / Nat Immunol 2002,3:281鈥?87. CrossRef
  35. Staub O, Yeger H, Plant P, Kim H, Ernst SA, Rotin D:Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na channel (ENaC). / Am J Physiol 1997,272:C1871鈥揅1880.
  36. Kamynina E, Debonneville C, Bens M, Vandewalle A, Staub O:A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. / FASEB J 2001,15:204鈥?14. CrossRef
  37. Harvey KF, Dinudom A, Cook DI, Kumar S:The Nedd4鈥搇ike Protein KIAA0439 Is a Potential Regulator of the Epithelial Sodium Channel. / J Biol Chem 2001,276:8597鈥?601. CrossRef
  38. Loffing-Cueni D, Flores SY, Sauter D, Daidie D, Siegrist N, Meneton P, Staub O, Loffing J:Dietary sodium intake regulates the ubiquitin-protein ligase nedd4鈥? in the renal collecting system. / J Am Soc Nephrol 2006,17:1264鈥?274. CrossRef
  39. Kumar S, Harvey KF, Kinoshita M, Copeland NG, Noda M, Jenkins NA:cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. / Genomics 1997,40:435鈥?43. CrossRef
  40. Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matusuda I, Endo F, Saya H, Nakao M:Human ubiquitin-protein ligase Nedd4: expression subcellular localization and selective interaction with ubiquitin-conjugating enzymes. / Genes to Cells 1999,3:751鈥?63. CrossRef
  41. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL:Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. / Mol Cell 2000,6:1365鈥?375. CrossRef
  42. Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D:Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb. / J Cell Biol 2000,149:1473鈥?484. CrossRef
  43. Kumar S, Tomooka Y, Noda M:Identification of a set of genes with developmentally down-regulated expression in the mouse brain. / Biochem Biophys Res Commun 1992,185:1155鈥?161. CrossRef
  44. Andr茅 B, Springael J-Y:WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3鈥揵inding Yes-associated protein YAP65. / Biochem Biophys Res Commun 1994,205:1201鈥?205. CrossRef
  45. Staub O, Dho S, Henry PC, Correa J, Ishikawa T, McGlade J, Rotin D:WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. / EMBO J 1996,15:2371鈥?380.
  46. Strack B, Calistri A, Accola MA, Palu G, Gottlinger HG:A role for ubiquitin ligase recruitment in retrovirus release. / Proc Natl Acad Sci USA 2000,97:13063鈥?3068. CrossRef
  47. Heissmeyer V, Macian F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A:Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. / Nat Immunol 2004,5:255鈥?65. CrossRef
  48. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH:A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. / Nature 1999,400:687鈥?93. CrossRef
  49. Massague J, Gomis RR:The logic of TGFbeta signaling. / FEBS Lett 2006,580:2811鈥?820. CrossRef
  50. Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R:Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. / Proc Natl Acad Sci USA 2001,98:974鈥?79. CrossRef
  51. Lo RS, Massague J:Ubiquitin-dependent degradation of TGF-beta-activated smad2. / Nat Cell Biol 1999,1:472鈥?78. CrossRef
  52. Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL:TGF-beta induces assembly of a Smad2鈥揝murf2 ubiquitin ligase complex that targets SnoN for degradation. / Nat Cell Biol 2001,3:587鈥?95. CrossRef
  53. Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K:Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. / J Biol Chem 2001,276:12477鈥?2480. CrossRef
  54. Murakami G, Watabe T, Takaoka K, Miyazono K, Imamura T:Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. / Mol Biol Cell 2003,14:2809鈥?817. CrossRef
  55. Perry WL, Hustad CM, Swing DA, O'Sullivan TN, Jenkins NA, Copeland NG:The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. / Nat Genet 1998,18:143鈥?46. CrossRef
  56. Walker LS, Abbas AK:The enemy within: keeping self-reactive T cells at bay in the periphery. / Nat Rev Immunol 2002,2:11鈥?9. CrossRef
  57. Mueller DL:E3 ubiquitin ligases as T cell anergy factors. / Nat Immunol 2004,5:883鈥?90. CrossRef
  58. Macian F, Garcia-Cozar F, Im SH, Horton HF, Byrne MC, Rao A:Transcriptional mechanisms underlying lymphocyte tolerance. / Cell 2002,109:719鈥?31. CrossRef
  59. Yang C, Zhou W, Jeon MS, Demydenko D, Harada Y, Zhou H, Liu YC:Negative Regulation of the E3 Ubiquitin Ligase Itch via Fyn-Mediated Tyrosine Phosphorylation. / Mol Cell 2006,21:135鈥?41. CrossRef
  60. Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M:Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. / Science 2004,306:271鈥?75. CrossRef
  61. Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, / et al.:Convergence of Itch-induced ubiquitination with MEKK1鈥揓NK signaling in Th2 tolerance and airway inflammation. / J Clin Invest 2006,116:1117鈥?126. CrossRef
  62. Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M:The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. / Cell 2006,124:601鈥?13. CrossRef
  63. Rossi M, De Laurenzi V, Munarriz E, Green DR, Liu YC, Vousden KH, Cesareni G, Melino G:The ubiquitin-protein ligase Itch regulates p73 stability. / EMBO J 2005,24:836鈥?48. CrossRef
  64. Rossi M, De Simone M, Pollice A, Santoro R, La Mantia G, Guerrini L, Calabro V:Itch/AIP4 associates with and promotes p63 protein degradation. / Cell Cycle 2006,5:1816鈥?822. CrossRef
  65. Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, Croce CM, Melino G:The E3 ubiquitin ligase Itch controls the protein stability of p63. / Proc Natl Acad Sci USA 2006,103:12753鈥?2758. CrossRef
  66. Miyazaki K, Ozaki T, Kato C, Hanamoto T, Fujita T, Irino S, Watanabe K, Nakagawa T, Nakagawara A:A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. / Biochem Biophys Res Commun 2003,308:106鈥?13. CrossRef
  67. Laine A, Ronai Z:Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. / Oncogene 2006, Aug 21, [Epub ahead of print]
  68. Huibregtse JM, Scheffner M, Howley PM:Cloning and expression of the cDNA for E6鈥揂P, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. / Mol Cell Biol 1993,13:775鈥?84.
  69. Kishino T, Lalande M, Wagstaff J:UBE3A/E6鈥揂P mutations cause Angelman syndrome. / Nat Genet 1997,15:70鈥?3. CrossRef
  70. Matsuura T, Sutcliffe JS, Fang P, Galjaard RJ, Jiang YH, Benton CS, Rommens JM, Beaudet AL:De novo truncating mutations in E6鈥揂P ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. / Nat Genet 1997,15:74鈥?7. CrossRef
  71. Vu TH, Hoffman AR:Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain. / Nature Genet 1997,17:12鈥?3. CrossRef
  72. Rougeulle C, Glatt H, Lalande M:The Angelman syndrome candidate gene, UBE3A/E6鈥揂P, is imprinted in brain. / Nature Genet 1997,17:14鈥?5. CrossRef
  73. zur Hausen H:Papillomaviruses and cancer: from basic studies to clinical application. / Nat Rev Cancer 2002,2:342鈥?50. CrossRef
  74. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM:The HPV鈥?6 E6 and E6鈥揂P complex functions as a ubiquitin-protein ligase in the ubiquitylation of p53. / Cell 1993,75:495鈥?05. CrossRef
  75. Nakagawa S, Huibregtse JM:Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. / Mol Cell Biol 2000,20:8244鈥?253. CrossRef
  76. Gewin L, Myers H, Kiyono T, Galloway DA:Identification of a novel telomerase repressor that interacts with the human papillomavirus type鈥?6 E6/E6鈥揂P complex. / Genes Dev 2004,18:2269鈥?282. CrossRef
  77. Mantovani F, Banks L:The human papillomavirus E6 protein and its contribution to malignant progression. / Oncogene 2001,20:7874鈥?887. CrossRef
  78. Scheffner M, Whitaker NJ:Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. / Semin Cancer Biol 2003,13:59鈥?7. CrossRef
  79. Kao WH, Beaudenon SL, Talis AL, Huibregtse JM, Howley PM:Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase. / J Virol 2000,74:6408鈥?417. CrossRef
  80. Mani A, Oh AS, Bowden ET, Lahusen T, Lorick KL, Weissman AM, Schlegel R, Wellstein A, Riegel AT:E6AP Mediates Regulated Proteasomal Degradation of the Nuclear Receptor Coactivator Amplified in Breast Cancer 1 in Immortalized Cells. / Cancer Res 2006,66:8680鈥?686. CrossRef
  81. Callaghan MJ, Russell AJ, Woollatt E, Sutherland GR, Sutherland RL, Watts CK:Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. / Oncogene 1998,17:3479鈥?491. CrossRef
  82. Clancy JL, Henderson MJ, Russell AJ, Anderson DW, Bova RJ, Campbell IG, Choong DY, Macdonald GA, Mann GJ, Nolan T, Brady G, Olopade OI, Woollatt E, Davies MJ, Segara D, Hacker NF, Henshall SM, Sutherland RL, Watts CK:EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. / Oncogene 2003,22:5070鈥?081. CrossRef
  83. Fuja TJ, Lin F, Osann KE, Bryant PJ:Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. / Cancer Res 2004,64:942鈥?51. CrossRef
  84. Deo RC, Sonenberg N, Burley SK:X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)鈥揵inding protein. / Proc Natl Acad Sci USA 2001,98:4414鈥?419. CrossRef
  85. Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M, Saya H, Nakao M:Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. / J Biol Chem 2002,277:3599鈥?605. CrossRef
  86. Henderson MJ, Russell AJ, Hird S, Munoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK:EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. / J Biol Chem 2002,277:26468鈥?6478. CrossRef
  87. Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, Gehring K:Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)鈥揵inding protein and a HECT ubiquitin ligase. / EMBO J 2004,23:272鈥?81. CrossRef
  88. Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK:EDD mediates DNA damage-induced activation of CHK2. / J Biol Chem 2006,281:39990鈥?0000. CrossRef
  89. Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N:Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. / EMBO J 2006,25:1934鈥?944. CrossRef
  90. Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R, Bernard S, Quarto M, Capra M, Goettig S, / et al.:The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. / Cell 2005,123:409鈥?21. CrossRef
  91. Gu J, Dubner R, Fornace AJ Jr, Iadarola MJ:UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation. / Oncogene 1995,11:2175鈥?178.
  92. Liu Z, Oughtred R, Wing SS:Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. / Mol Cell Biol 2005,25:2819鈥?831. CrossRef
  93. Chen D, Kon N, Li M, Zhang W, Qin J, Gu W:ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. / Cell 2005,121:1071鈥?083. CrossRef
  94. Zhong Q, Gao W, Du F, Wang X:Mule/ARF-BP1, a BH3鈥搊nly E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl鈥? and regulates apoptosis. / Cell 2005,121:1085鈥?095. CrossRef
  95. Chen D, Brooks CL, Gu W:ARF-BP1 as a potential therapeutic target. / Br J Cancer 2006,94:1555鈥?558.
  96. Walkowicz M, Ji Y, Ren X, Horsthemke B, Russell LB, Johnson D, Rinchik EM, Nicholls RD, Stubbs L:Molecular characterization of radiation鈥?and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice. / Mamm Genome 1999,10:870鈥?78. CrossRef
  97. Liddle GW, Bledsoe T, Coppage WS Jr:A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. / Trans Assoc Am Physicians 1963,76:199鈥?13.
  98. Botero-Velez M, Curtis JJ, Warnock DG:Brief report: Liddles's syndrome revisited. / N Engl J Med 1994,330:178鈥?81. CrossRef
  99. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW, / et al.:Liddle's syndrome: heritable human hypertension caused by mutations in the 尾 subunit of the epithelial sodium channel. / Cell 1994,79:407鈥?14. CrossRef
  100. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets RA, Lu Y, Canessa CM, Iwasaki T, Rossier BC, Lifton RP:Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome. / Nat Genet 1995,11:76鈥?2. CrossRef
  101. Kanelis V, Rotin D, Forman-Kay JD:Solution structure of a Nedd4 WW domain-ENaC peptide complex. / Nat Struct Biol 2001,8:1鈥?. CrossRef
  102. Snyder PM, Steines JC, Olson DR:Relative contribution of Nedd4 and Nedd4鈥? to ENaC regulation in epithelia determined by RNA interference. / J Biol Chem 2004,279:5042鈥?046. CrossRef
  103. Harvey KF, Dinudom A, Komwatana P, Jolliffe CN, Day ML, Parasivam G, Cook DI, Kumar S:All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. / J Biol Chem 1999,274:12525鈥?2530. CrossRef
  104. Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T:14鈥?鈥? proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4鈥? ubiquitin ligase. / J Biol Chem 2005,280:13187鈥?3194. CrossRef
  105. Loffing J, Flores SY, Staub O:Sgk kinases and their role in epithelial transport. / Annu Rev Physiol 2006,68:461鈥?90. CrossRef
  106. Russo CJ, Melista E, Cui J, DeStefano AL, Bakris GL, Manolis AJ, Gavras H, Baldwin CT:Association of NEDD4L ubiquitin ligase with essential hypertension. / Hypertension 2005,46:488鈥?91. CrossRef
  107. Demirov DG, Freed EO:Retrovirus budding. / Virus Res 2004,106:87鈥?02. CrossRef
  108. Staub O, Rotin D:Role of ubiquitylation in cellular membrane transport. / Physiol Rev 2006,86:669鈥?07. CrossRef
  109. Medina G, Zhang Y, Tang Y, Gottwein E, Vana ML, Bouamr F, Leis J, Carter CA:The functionally exchangeable L domains in RSV and HIV鈥? Gag direct particle release through pathways linked by Tsg101. / Traffic 2005,6:880鈥?94. CrossRef
  110. Derynck R, Akhurst RJ, Balmain A:TGF-beta signaling in tumor suppression and cancer progression. / Nat Genet 2001,29:117鈥?29. CrossRef
  111. Izzi L, Attisano L:Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. / Oncogene 2004,23:2071鈥?078. CrossRef
  112. Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A:The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. / Br J Cancer 2003,89:1538鈥?544. CrossRef
  113. Ying SX, Hussain ZJ, Zhang YE:Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein鈥?鈥搃nduced osteoblast conversion by targeting Smad5 for degradation. / J Biol Chem 2003,278:39029鈥?9036. CrossRef
  114. Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D:Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. / J Biol Chem 2004,279:12854鈥?2859. CrossRef
  115. Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D:E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. / J Biol Chem 2003,278:27939鈥?7944. CrossRef
  116. Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'Keefe RJ, Chen D:Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1鈥搃nduced Runx2 degradation. / J Biol Chem 2006,281:3569鈥?576. CrossRef
  117. Yamashita M, Ying SX, Zhang GM, Li C, Cheng SY, Deng CX, Zhang YE:Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. / Cell 2005,121:101鈥?13. CrossRef
  118. Pan H, Griep AE:Altered cell cycle regulation in the lens of HPV鈥?6 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. / Genes Dev 1994,8:1285鈥?299. CrossRef
  119. Simonson SJ, Difilippantonio MJ, Lambert PF:Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential. / Cancer Res 2005,65:8266鈥?273. CrossRef
  120. Beer-Romero P, Glass S, Rolfe M:Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. / Oncogene 1997,14:595鈥?02. CrossRef
  121. Kim Y, Cairns MJ, Marouga R, Sun LQ:E6AP gene suppression and characterization with in vitro selected hammerhead ribozymes. / Cancer Gene Ther 2003,10:707鈥?16. CrossRef
  122. Kelley ML, Keiger KE, Lee CJ, Huibregtse JM:The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase. / J Virol 2005,79:3737鈥?747. CrossRef
  123. Hengstermann A, D'silva MA, Kuballa P, Butz K, Hoppe-Seyler F, Scheffner M:Growth suppression induced by downregulation of E6鈥揂P expression in human papillomavirus-positive cancer cell lines depends on p53. / J Virol 2005,79:9296鈥?2300. CrossRef
  124. Angelman H:"Puppet children". A report of three cases. / Dev Med Child Neurol 1965,7:681鈥?88. CrossRef
  125. Clayton-Smith J, Laan L:Angelman syndrome: a review of the clinical and genetic aspects. / J Med Genet 2003,40:87鈥?5. CrossRef
  126. Fang P, Lev-Lehman E, Tsai TF, Matsuura T, Benton CS, Sutcliffe JS, Christian SL, Kubota T, Halley DJ, Meijers-Heijboer H, / et al.:The spectrum of mutations in UBE3A causing Angelman syndrome. / Hum Mol Genet 1999,8:129鈥?35. CrossRef
  127. Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW:The Angelman syndrome-associated protein, E6鈥揂P, is a coactivator for the nuclear hormone receptor superfamily. / Mol Cell Biol 1999,19:1182鈥?189.
  128. Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet AL:Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. / Neuron 1998,21:799鈥?11. CrossRef
  129. Miura K, Kishino T, Li E, Webber H, Dikkes P, Holmes GL, Wagstaff J:Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice. / Neurobiol Dis 2002,9:149鈥?59. CrossRef
  130. Albrecht U, Sutcliffe JS, Cattanach BM, Beechey CV, Armstrong D, Eichele G, Beaudet AL:Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons. / Nat Genet 1997,17:75鈥?8. CrossRef
  131. Mansfield E, Hersperger E, Biggs J, Shearn A:Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. / Dev Biol 1994,165:507鈥?26. CrossRef
  132. Saunders DN, Hird SL, Withington SL, Dunwoodie SL, Henderson MJ, Biben C, Sutherland RL, Ormandy CJ, Watts CK:Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. / Mol Cell Biol 2004,24:7225鈥?234. CrossRef
  133. Lee JD, Amanai K, Shearn A, Treisman JE:The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. / Development 2002,129:5697鈥?706. CrossRef
  134. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. / Science 2004,303:844鈥?48. CrossRef
  
• 作者单位：Martin Scheffner (1)
  Olivier Staub (2)
  
  1. Department of Biology, University of Konstanz, 78457, Konstanz, Germany
  2. Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, 1005, Lausanne, Switzerland
  

文摘

In a simplified view, members of the HECT E3 family have a modular structure consisting of the C-terminal HECT domain, which is catalytically involved in the attachment of ubiquitin to substrate proteins, and N-terminal extensions of variable length and sequence that mediate the substrate specificity of the respective HECT E3. Although the physiologically relevant substrates of most HECT E3s have remained elusive, it is becoming increasingly clear that HECT E3s play an important role in sporadic and hereditary human diseases including cancer, cardiovascular (Liddle's syndrome) and neurological (Angelman syndrome) disorders, and/or in disease-relevant processes including bone homeostasis, immune response and retroviral budding. Thus, molecular approaches to target the activity of distinct HECT E3s, regulators thereof, and/or of HECT E3 substrates could prove valuable in the treatment of the respective diseases. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).