Scheimpflug-Fotografie detektiert Ver?nderungen der Hornhautdichte und Hornhautdicke bei Patienten mit Keratoconjunctivitis sicca

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• 作者：Dr. L.M. Meyer PhD (1)
  M. Kronschl?ger (2)
  A.R. Wegener (3)
  
• 关键词：Trockenes Auge ; Hornhautgewebe ; Hornhautschicht ; Hornhaut ; Hornhautanatomie ; Dry eye syndrome ; Corneal tissue ; Corneal layer ; Cornea ; Corneal anatomy
• 刊名：Der Ophthalmologe
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：111
• 期：10
• 页码：914-919
• 全文大小：448 KB
• 参考文献：1. G?bbels M, Gross D (1996) Klinische Studie zur Wirksamkeit eines dexapanthenolhaltigen Tr?nenersatzmittels (Siccaprotect) bei der Behandlung Trockener Augen. Klin Monatsbl Augenheilkd 209:84-8 CrossRef
  2. Bericht des Unterausschusses für Definition und Klassifikation des International Dry Eye Workshop (2007). Ocul Surf 5:2. http://www.tearfilmorg/dewsreport
  3. Pflugfelder SC (2008) Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care 14(Suppl):102-06
  4. Ruprecht KW, Schirra F (2001) Epidemiologie des Trockenen Auges. In: Brewitt H, Zierhut M (Hrsg) Trockenes Auge. Kaden, Heidelberg, S?57-0
  5. Hockwin O, Dragomirescu V, Laser H (1982) Measurements of lens transparency or its disturbances by densitometric image analysis of Scheimpflug photographs. Graefes Arch Clin Exp Ophthalmol 219:255-62 CrossRef
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  10. Gilbard JP (1985) Tear film osmolarity and keratoconjunctivitis sicca. CLAO J 11:243-50
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  12. Pole J, Batzer J (1985) Central corneal thickness of patients with dry eyes. J Am Optom Assoc 56(3):220-21
  13. Hovding G (1992) The central corneal thickness in keratoconjunctivitis sicca. Acta Ophthalmol 70:108-10 CrossRef
  14. Liu Z, Pflugfelder SC (1999) Corneal thickness is reduced in dry eye. Cornea 18(4):403-07 CrossRef
  15. Liu Z, Pflugfelder SC (1999) Corneal surface regularity and the effect of artificial tears in aqueous tear deficiancy. Ophthalmology 106(5):939-43 CrossRef
  16. Wilkinson BR (1999) Dry eye syndrome. Ophthalmology 106:1044 CrossRef
  
• 作者单位：Dr. L.M. Meyer PhD (1)
  M. Kronschl?ger (2)
  A.R. Wegener (3)
  
  1. Augenklinik Herzog Carl Theodor, Nymphenburger Str. 43, 80335, München, Deutschland
  2. Universit?t Uppsala, Uppsala, Schweden
  3. Universit?ts-Augenklinik Bonn, Bonn, Deutschland
  
• ISSN：1433-0423

文摘

Background Dry eye disease is a common ocular surface disease that significantly affects the quality of life. Little is known about a potential impact of the disease on corneal morphology. This study was carried out to investigate for the first time if dry eye disease induces changes in corneal density and thickness. Methods In total 97 patients suffering from dry eye disease and 33 healthy age-matched individuals were included in this prospective, randomized study. Corneal morphology was documented with Scheimpflug photography and analyzed for central corneal thickness and corneal density in five anatomical layers (i.e. epithelium, Bowman membrane, corneal stroma, Descemet membrane and endothelium). Results Corneal density was significantly reduced in the epithelium (p--.0053), Bowman membrane (p--.0049) and Descemet’s membrane (p--.0385) in patients with dry eye syndrome compared to healthy controls. This decrease was age-dependant. Furthermore, central corneal thickness was significantly reduced in patients with dry eye syndrome compared to the control group (p--.0495). The change was again dependent on age with lower values at higher age. Central corneal thickness increased with age in the control group. Conclusion The results of this study indicate that corneal morphology is subject to significant alterations in patients with dry eye disease. Scheimpflug photography provides not only unique information in lens trials but is also able to detect changes of corneal anatomy. However, further investigations with other anterior segment imaging techniques, such spectral domain optical coherence tomography (SD OCT/Pentacam?) are necessary to further evaluate the clinical consequences of these findings.