Attitudes of parents of Klinefelter boys and pediatricians towards neonatal screening and fertility preservation techniques in Klinefelter syndrome

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• 作者：Inge Gies ; Herman Tournaye ; Jean De Schepper
• 关键词：Klinefelter syndrome ; Fertility preservation ; Neonatal screening ; Pubertal
• 刊名：European Journal of Pediatrics
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：175
• 期：3
• 页码：399-404
• 全文大小：497 KB
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• 作者单位：Inge Gies (1)
  Herman Tournaye (2) (3)
  Jean De Schepper (1)
  
  1. Division of Pediatric Endocrinology, Pediatric Department, UZ Brussel, Laarbeeklaan 101, B1090, Brussels, Belgium
  2. Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, B1090, Brussels, Belgium
  3. BITE Research Group, Vrije Universiteit Brussel, Brussels, Belgium
  
• 刊物主题：Pediatrics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1076

文摘

To evaluate the attitude of parents of Klinefelter syndrome (KS) boys and pediatricians with regard to early detection of KS and fertility preservation, a specific questionnaire investigating the acceptability towards neonatal screening for KS and the use of testicular biopsy and sperm collection was designed. The responses of 49 pediatricians and 18 parents were evaluated. All parents and 67 % of the pediatricians consider neonatal screening for KS to be a good option. A total of 83.3 % of the parents agree on performing a testicular biopsy in their pubertal KS boy, 72.2 % are in favor of banking spermatozoa after masturbation while 77.7 % agree on spermatozoa banking after penile vibro-stimulation or rectal electro-stimulation under general anesthesia. Sixty-nine percent of pediatricians would counsel parents and KS adolescents in favor of early detection and cryopreservation of spermatozoa after masturbation, and 71.2 % agrees on testicular biopsy to detect spermatozoa or eventually spermatogonial stem cells (SSCs) for cryopreservation in minor KS patients.