In silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressure
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- 作者：Aleksandra A. Chertkova ; Joshua S. Schiffman ; Sergey V. Nuzhdin…
- 关键词：Evolution ; Regulatory sequence ; Gap gene regulatory network ; Thermodynamic expression model ; Drosophila development
- 刊名：BMC Evolutionary Biology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：17
- 期：1-supp
- 全文大小：1123KB
- 刊物主题：Evolutionary Biology; Animal Systematics/Taxonomy/ Biogeography; Entomology; Genetics and Population Dynamics; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2148
- 卷排序：17
文摘
BackgroundCis-regulatory sequences are often composed of many low-affinity transcription factor binding sites (TFBSs). Determining the evolutionary and functional importance of regulatory sequence composition is impeded without a detailed knowledge of the genotype-phenotype map.