Molecular imaging of inflammation and intraplaque vasa vasorum: A step forward to identification of vulnerable plaques?

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• 作者：Gerrit L. ten Kate MD (1) (2)
  Eric J. G. Sijbrands MD ; PhD (1)
  Roelf Valkema MD ; PhD (3)
  Folkert J. ten Cate MD ; PhD (2)
  Steven B. Feinstein MD (4)
  Antonius F. W. van der Steen PhD (5)
  Mat J. A. P. Daemen MD ; PhD (6)
  Arend F. L. Schinkel MD ; PhD (1) (2)
  
• 关键词：Atherosclerosis ; angiogenesis ; inflammation ; molecular imaging ; vasa vasorum ; vulnerable atherosclerotic plaque
• 刊名：Journal of Nuclear Cardiology
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：17
• 期：5
• 页码：897-912
• 全文大小：1048KB
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• 作者单位：Gerrit L. ten Kate MD (1) (2)
  Eric J. G. Sijbrands MD, PhD (1)
  Roelf Valkema MD, PhD (3)
  Folkert J. ten Cate MD, PhD (2)
  Steven B. Feinstein MD (4)
  Antonius F. W. van der Steen PhD (5)
  Mat J. A. P. Daemen MD, PhD (6)
  Arend F. L. Schinkel MD, PhD (1) (2)
  
  1. Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
  2. Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
  3. Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
  4. Section of Cardiology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
  5. Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
  6. Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
  

文摘

Current developments in cardiovascular biology and imaging enable the noninvasive molecular evaluation of atherosclerotic vascular disease. Intraplaque neovascularization sprouting from the adventitial vasa vasorum has been identified as an independent predictor of intraplaque hemorrhage and plaque rupture. These intraplaque vasa vasorum result from angiogenesis, most likely under influence of hypoxic and inflammatory stimuli. Several molecular imaging techniques are currently available. Most experience has been obtained with molecular imaging using positron emission tomography and single photon emission computed tomography. Recently, the development of targeted contrast agents has allowed molecular imaging with magnetic resonance imaging, ultrasound and computed tomography. The present review discusses the use of these molecular imaging techniques to identify inflammation and intraplaque vasa vasorum to identify vulnerable atherosclerotic plaques at risk of rupture and thrombosis. The available literature on molecular imaging techniques and molecular targets associated with inflammation and angiogenesis is discussed, and the clinical applications of molecular cardiovascular imaging and the use of molecular techniques for local drug delivery are addressed.