On the interaction of different types of ligands binding to the same molecule Part II: systems with n to 2 and n to 3 binding sites

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• 作者：Johannes W. R. Martini (1)
  Martin Schlather (2)
  G. Matthias Ullmann (3)
  
• 关键词：Decoupled sites representation ; Protonation ; Binding polynomial ; Interaction energy ; Binding energy ; Ligand binding ; Electron transfer ; Photosynthesis ; Receptor
• 刊名：Journal of Mathematical Chemistry
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：51
• 期：2
• 页码：696-714
• 全文大小：491KB
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• 作者单位：Johannes W. R. Martini (1)
  Martin Schlather (2)
  G. Matthias Ullmann (3)
  
  1. Institut f眉r Mathematische Stochastik, Georg-August Universit盲t G枚ttingen, G枚ttingen, Germany
  2. Institut f眉r Mathematik, Universit盲t Mannheim, Mannheim, Germany
  3. Bioinformatik/Strukturbiologie, Universit盲t Bayreuth, Bayreuth, Germany
  
• ISSN：1572-8897

文摘

In the first part of this work we formulated the decoupled sites representation for two different types of ligands and highlighted special properties of the case of n binding sites for ligand L 1 and one binding site for ligand L 2. Moreover, for this case, we identified the microstate constants as unique components all decoupled molecules share. In the second part on hand, we investigate the cases with (n, 2) and (n, 3) binding sites. As it is difficult to solve the system of equations occurring when a molecule with more than one binding site for both ligands shall be decoupled, we present applicable calculation methods which exploit the special structure of the system of equations. Moreover, we investigate which unique properties all decoupled molecules share and show that for two different decoupled molecules with the same binding polynomial, not all microstate constants of a certain macrostate are permutations of the microstate constants of the other molecule.