Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study

详细信息    查看全文

• 作者：Lucia J. M. Kroft (1)
  Noortje van der Bijl (1)
  Jeroen van der Grond (1)
  Irmhild Altmann-Schneider (1) (2)
  Pieternella E. Slagboom (2) (3)
  Rudolf G. J. Westendorp (2) (4)
  Albert de Roos (1)
  Antonius J. M. de Craen (2) (5)
  
• 关键词：Aging ; Calcium score ; Computed tomography ; Longevity ; Nonagenarian ; Offspring
• 刊名：AGE
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：36
• 期：4
• 全文大小：520 KB
• 参考文献：1. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15:827-32 CrossRef
  2. Bellasi A, Lacey C, Taylor AJ, Raggi P, Wilson PW, Budoff MJ, Vaccarino V, Shaw LJ (2007) Comparison of prognostic usefulness of coronary artery calcium in men versus women (results from a meta- and pooled analysis estimating all-cause mortality and coronary heart disease death or myocardial infarction). Am J Cardiol 100:409-14 j.amjcard.2007.03.037" target="_blank" title="It opens in new window">CrossRef
  3. Blaha M, Budoff MJ, Shaw LJ, Khosa F, Rumberger JA, Berman D, Callister T, Raggi P, Blumenthal RS, Nasir K (2009) Absence of coronary artery calcification and all-cause mortality. JACC Cardiovasc Imaging 2:692-00 j.jcmg.2009.03.009" target="_blank" title="It opens in new window">CrossRef
  4. Budoff MJ, Shokooh S, Shavelle RM, Kim HT, French WJ (2002) Electron beam tomography and angiography: sex differences. Am Heart J 143:877-82 j.2002.121737" target="_blank" title="It opens in new window">CrossRef
  5. Budoff MJ, Shaw LJ, Liu ST, Weinstein SR, Mosler TP, Tseng PH, Flores FR, Callister TQ, Raggi P, Berman DS (2007) Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. J Am Coll Cardiol 49:1860-870 j.jacc.2006.10.079" target="_blank" title="It opens in new window">CrossRef
  6. Geluk CA, Dikkers R, Perik PJ, Tio RA, G?tte MJ, Hillege HL, Vliegenthart R, Houwers JB, Willems TP, Oudkerk M, Zijlstra F (2008) Measurement of coronary calcium scores by electron beam computed tomography or exercise testing as initial diagnostic tool in low-risk patients with suspected coronary artery disease. Eur Radiol 18:244-52 CrossRef
  7. Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC (2004) Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 291:210-15 jama.291.2.210" target="_blank" title="It opens in new window">CrossRef
  8. Greenland P, Bonow RO, Brundage BH, Budoff MJ, Eisenberg MJ, Grundy SM, Lauer MS, Post WS, Raggi P, Redberg RF, Rodgers GP, Shaw LJ, Taylor AJ, Weintraub WS (2007) ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 49:378-02 j.jacc.2006.10.001" target="_blank" title="It opens in new window">CrossRef
  9. Hoff JA, Chomka EV, Krainik AJ, Daviglus M, Rich S, Kondos GT (2001) Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults. Am J Cardiol 87:1335-339 CrossRef
  10. Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, Sheedy PF II, Peyser PA, Schwartz RS (2001) Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation 104:412-17 CrossRef
  11. Kondos GT, Hoff JA, Sevrukov A, Daviglus ML, Garside DB, Devries SS, Chomka EV, Liu K (2003) Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation 107:2571-576 CrossRef
  12. McClelland RL, Nasir K, Budoff M, Blumenthal RS, Kronmal RA (2009) Arterial age as a function of coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol 103:59-3. doi:10.1016/j.amjcard.2008.08.031 j.amjcard.2008.08.031" target="_blank" title="It opens in new window">CrossRef
  13. Raggi P, Shaw LJ, Berman DS, Callister TQ (2004) Prognostic value of coronary artery calcium screening in subjects with and without diabetes. J Am Coll Cardiol 43:1663-669 j.jacc.2003.09.068" target="_blank" title="It opens in new window">CrossRef
  14. Raggi P, Gongora MC, Gopal A, Callister TQ, Budoff M, Shaw LJ (2008) Coronary artery calcium to predict all-cause mortality in elderly men and women. J Am Coll Cardiol 52:17-3. doi:10.1016/j.jacc.2008.04.004 j.jacc.2008.04.004" target="_blank" title="It opens in new window">CrossRef
  15. Rumberger JA, Brundage BH, Rader DJ, Kondos G (1999) Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic individuals. Mayo Clin Proc 74:243-52 CrossRef
  16. Schoenmaker M, de Craen AJ, de Meijer PH, Beekman M, Blauw GJ, Slagboom PE, Westendorp RG (2006) Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet 14:79-4
  17. Shaw LJ, Raggi P, Schisterman E, Berman DS, Callister TQ (2003) Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality. Radiology 228:826-33 CrossRef
  18. Shaw LJ, Raggi P, Berman DS, Callister TQ (2006a) Coronary artery calcium as a measure of biologic age. Atherosclerosis 188:112-19 j.atherosclerosis.2005.10.010" target="_blank" title="It opens in new window">CrossRef
  19. Shaw LJ, Raggi P, Callister TQ, Berman DS (2006b) Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokers. Eur Heart J 27:968-75 j/ehi750" target="_blank" title="It opens in new window">CrossRef
  20. Taylor AJ, Bindeman J, Feuerstein I, Cao F, Brazaitis M, O'Malley PG (2005) Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. J Am Coll Cardiol 46:807-14 j.jacc.2005.05.049" target="_blank" title="It opens in new window">CrossRef
  21. Tota-Maharaj R, Blaha MJ, McEvoy JW, Blumenthal RS, Muse ED, Budoff MJ, Shaw LJ, Berman DS, Rana JS, Rumberger J, Callister T, Rivera J, Agatston A, Nasir K (2012) Coronary artery calcium for the prediction of mortality in young adults <45?years old and elderly adults >75?years old. Eur Heart J 33:2955-962. doi:10.1093/eurheartj/ehs230 j/ehs230" target="_blank" title="It opens in new window">CrossRef
  22. Vliegenthart R, Oudkerk M, Hofman A, Oei HH, van Dijck W, van Rooij FJ, Witteman JC (2005) Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation 112:572-77 CrossRef
  23. Westendorp RG, van Heemst D, Rozing MP, Fr?lich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE, Leiden Longevity Study Group (2009) Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: the Leiden Longevity Study. J Am Geriatr Soc 57:1634-637. doi:10.1111/j.1532-5415.2009.02381.x j.1532-5415.2009.02381.x" target="_blank" title="It opens in new window">CrossRef
  
• 作者单位：Lucia J. M. Kroft (1)
  Noortje van der Bijl (1)
  Jeroen van der Grond (1)
  Irmhild Altmann-Schneider (1) (2)
  Pieternella E. Slagboom (2) (3)
  Rudolf G. J. Westendorp (2) (4)
  Albert de Roos (1)
  Antonius J. M. de Craen (2) (5)
  
  1. Department of Radiology, C2S, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
  2. Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
  3. Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
  4. Leyden Academy on Vitality and Ageing, Leiden, The Netherlands
  5. Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands
  
• ISSN：1574-4647

文摘

Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measured in offspring of long-lived families (n--44, 125 males) and their partners (n--23, 96 males) who served as controls. Calcium scores were analyzed separately for sexes. Subjects were grouped by very low calcium score ?0 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between calcium scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower calcium scores than controls. In men, 34?% of offspring had score ?0 versus 21?% of controls (odds ratio (OR) and 95?% confidence interval (CI) 2.0, 1.08-.7, p--.028). In women, 70?% of offspring had score ?0 versus 54?% of controls (OR 1.9, 95?% CI 1.13-.4, p--.019). Differences remained significant after correction for age (men, p--.043 and women, p--.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores. In men, the association was found to be influenced by cardiovascular risk factors. Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.