Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report
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- 作者：Ali R Elyassi (1)
Robert P Long (1)
Robert P Bejnarowicz (1)
Bruce A Schoneboom (1) - 刊名：Journal of Medical Case Reports
- 出版年：2011
- 出版时间：December 2011
- 年：2011
- 卷：5
- 期：1
- 全文大小：1848KB
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Robert P Long (1)
Robert P Bejnarowicz (1)
Bruce A Schoneboom (1)
1. Department of Surgery, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI, 96859-5000, USA
文摘
Introduction The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor documentation whether or not gabapentin and ketamine interact to cause prolonged depression of the central nervous system. Case Presentation The following is a case report in which a patient, a 58-year-old African-American man, with a history of post-traumatic stress disorder and chronic pain underwent a cervical laminoplasty procedure. The patient presented post-operatively in a dissociative state with paralysis, anarthria and preservation of consciousness. All organic causes were excluded, with the exception of prolonged central nervous system depression from a gabapentin/ketamine drug interaction. A new onset conversion disorder could also not be excluded. Conclusion Although this case by itself is not enough evidence to substantiate a true adverse reaction between gabapentin and ketamine, it is enough to warrant further investigation.