Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling

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• 作者：Joyce A. Schroeder ; Leslie F. Jackson ; David C. Lee and Todd D. Camenisch
• 关键词：Endocardial cushion morphogenesis ; Heart valve ; erbB ; Hyaluronan ; Extracellular matrix
• 刊名：Journal of Molecular Medicine
• 出版年：2003
• 出版时间：July 2003
• 年：2003
• 卷：81
• 期：7
• 页码：392-403
• 全文大小：514 KB

文摘

It is becoming clear that converging pathways coordinate early heart valve development and remodeling into functional valve leaflets. The integration of these pathways begins with macro and molecular interactions outside the cell in the extracellular matrix separating the myocardial and endocardial tissue components of the rudimentary heart. Such interactions regulate events at the cell surface through receptors, proteases, and other membrane molecules which in turn transduce signals into the cell. These signals trigger intracellular cascades that transduce cellular responses through both transcription factor and cofactor activation mediating gene induction or suppression. Chamber septation and valve formation occur from these coordinated molecular events within the endocardial cushions to sustain unidirectional blood flow and embryo viability. This review discusses the emerging connection between extracellular matrix and growth factor receptor signaling during endocardial cushion morphogenesis by highlighting the extracellular component, hyaluronan, and erbB receptor functions during early valve development.