Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke
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- 作者：Michael K. Schuhmann ; Josua Guthmann ; Guido Stoll…
- 关键词：Ischemic stroke ; Transient middle cerebral artery occlusion ; Glycoprotein receptor Ib ; Thrombo ; inflammation
- 刊名：Journal of Neuroinflammation
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：825KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
- 卷排序：14
文摘
BackgroundIschemic stroke causes a strong inflammatory response that includes T cells, monocytes/macrophages, and neutrophils. Interaction of these immune cells with platelets and endothelial cells facilitates microvascular dysfunction and leads to secondary infarct growth. We recently showed that blocking of platelet glycoprotein (GP) receptor Ib improves stroke outcome without increasing the risk of intracerebral hemorrhage. Until now, it has been unclear whether GPIb only mediates thrombus formation or also contributes to the pathophysiology of local inflammation.