Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects

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• 作者：Henrietta Ho ; Mineo Ozaki…
• 关键词：Glaucoma ; Angle closure ; Ethnicity ; Anterior segment optical coherence tomography
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：253
• 期：4
• 页码：601-608
• 全文大小：262 KB
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  17. Wang, D, Huang, G, He, M, Wu, L, Lin, S (2012) Comparison of anterior ocular segment biometry featu
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Purpose To compare anterior segment parameters in Chinese and Japanese subjects with angle closure using anterior segment optical coherence tomography (ASOCT). Methods One hundred and forty-two Japanese and one hundred and ninety-two Chinese subjects with primary angle closure (PAC) or primary angle-closure glaucoma (PACG) were recruited. All participants underwent A-scan biometry and ASOCT imaging (Visante, Carl Zeiss Meditec, Dublin, CA, USA). Customized software was used to measure ASOCT parameters in horizontal ASOCT scans. The parameters were compared, and multivariate analysis was performed to determine predictors of angle opening distance at 750?μm from the scleral spur (AOD750). Results Ethnic difference evaluated by multiple linear regression adjusted for age, gender, spherical equivalent, pupil diameter, and axial length showed that Japanese angle-closure subjects had significantly shallower anterior chamber depth (ACD;β-??0.3, p--.001), smaller anterior chamber area (ACA; β-??0.21, p--.02) and volume (ACV; β-??0.19, p--.01), greater lens vault (LV, β--.3, p--.001), lens thickness (LT; β--.48, p--.001), greater iris area (IArea; β--.19, p--.01), and more curved iris (ICurv; β--.16, p--.04). The significant determinants of AOD750 were iris thickness (IT; β-??0.21, p--.04), ICurv (β-??0.17, p--.04), pupil diameter (PD; β-??0.34, p--.001) and ACV (β--.32, p--.001) in Japanese; and IT (β-??0.25, p--.001), ACV (β--.37, p--.001), PD (β-??0.26, p--.001), and LV (β-??0.18, p--.03) in Chinese. Conclusions Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses. ACV, IT, and PD are important factors for angle width in both races. These results suggest possible ethnic differences in angle-closure mechanism(s).