Innate Immunity in Systemic Sclerosis

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• 作者：Christopher Dowson ; Nathan Simpson ; Laura Duffy…
• 关键词：Systemic sclerosis ; SSc ; Scleroderma ; Autoimmune disease
• 刊名：Current Rheumatology Reports
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：
• 刊物主题：Rheumatology;
• 出版者：Springer US
• ISSN：1534-6307
• 卷排序：19

文摘

Purpose of ReviewSystemic sclerosis (SSc) is a heterogeneous autoimmune disease which has defined three hallmarks: Small vessel vasculopathy, production of autoantibodies and fibroblast dysfunction. The exact aetiology of the disease remains unknown, due to the complex nature of the cellular signalling pathways involved. However, there is strong and consistent evidence that the innate system, in particular toll-like receptor signalling, is contributing to the progression and perhaps onset of systemic sclerosis. In light of this evidence, this review examines the role of innate immunity in systemic sclerosis and where appropriate suggests avenues for therapeutic modulation in SSc.