Scopolamine disrupts place navigation in rats and humans: a translational validation of the Hidden Goal Task in the Morris water maze and a real maze for humans
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- 作者：Jan Laczó ; Hana Markova ; Veronika Lobellova ; Ivana Gazova…
- 关键词：Spatial orientation ; Scopolamine ; Acetylcholinesterase inhibitor ; Human ; Rat
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：234
- 期：4
- 页码：535-547
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
RationaleDevelopment of new drugs for treatment of Alzheimer’s disease (AD) requires valid paradigms for testing their efficacy and sensitive tests validated in translational research.