1,25-dihydroxyvitamin D3 inhibits corneal wound healing in an ex-vivo mouse model
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- 作者：Saadettin Sel ; Stefanie Trau…
- 关键词：1 ; 25 ; dihydroxyvitamin D3 ; Corneal wound healing ; Human corneal epithelial cells ; Scratch assay ; Ex ; vivo model
- 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：254
- 期：4
- 页码：717-724
- 全文大小：539 KB
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Stefanie Trau (1)
Friedrich Paulsen (3)
Thomas Kalinski (4)
Gabriele I. Stangl (2)
Norbert Nass (1) (4)
5. Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
1. Department of Ophthalmology, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany
3. Department of Anatomy II, University of Erlangen-Nürnberg, Erlangen, Germany
4. Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Str. 44, D-39120, Magdeburg, Germany
2. Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Ophthalmology - 出版者：Springer Berlin / Heidelberg
- ISSN：1435-702X
文摘
Purpose Impaired healing of corneal injuries can result in ulceration and complete loss of vision, especially in the elderly. Such patients frequently also exhibit vitamin D insufficiency. 1,25-dihydroxyvitamin D3 is the active vitamin D metabolite. As it affects cell proliferation and inflammation, we herein aimed at elucidating its influence on corneal wound healing after alkali burn by using in vitro and ex vivo techniques.