Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients

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• 作者：Jens Köhler ; Martin Schuler…
• 关键词：Lung cancer ; RNU2 ; 1f ; Serum biomarker ; Diagnostic ; Prognostic ; Treatment monitoring
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：142
• 期：4
• 页码：795-805
• 全文大小：796 KB
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• 作者单位：Jens Köhler (1) (12)
  Martin Schuler (1) (2)
  Thomas Christoph Gauler (1)
  Stefanie Nöpel-Dünnebacke (11) (3)
  Maike Ahrens (4)
  Andreas-Claudius Hoffmann (1)
  Stefan Kasper (1) (2)
  Felix Nensa (5)
  Benedikt Gomez (6)
  Maria Hahnemann (5)
  Frank Breitenbuecher (1) (2)
  Danjouma Cheufou (7)
  Filiz Özkan (8)
  Kaid Darwiche (8)
  Mathias Hoiczyk (1)
  Henning Reis (9)
  Stefan Welter (7)
  Wilfried Ernst Erich Eberhardt (1)
  Martin Eisenacher (4)
  Helmut Teschler (10)
  Georgios Stamatis (7)
  Wolff Schmiegel (11)
  Stephan Albrecht Hahn (3)
  Alexander Baraniskin (11) (3)
  
  1. Division of Thoracic Oncology, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany
  12. Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
  2. German Cancer Consortium (DKTK), 69120, Heidelberg, Germany
  11. Department of Internal Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany
  3. Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany
  4. Medizinisches Proteom-Center, Bioinformatics/Biostatistics, Ruhr-University Bochum, Bochum, Germany
  5. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  6. Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  7. Department of Thoracic Surgery, Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  8. Department of Interventional Pneumonology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  9. Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  10. Department of Pneumonology, Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335

文摘

Purpose Lung cancer accounts for one in five cancer deaths. Broad screening strategies for high-risk populations are unavailable, and the validation of biomarkers for early cancer detection remains a prime interest. Therefore, we investigated the value of circulating U2 small nuclear RNA fragments (RNU2-1f) as a biomarker for diagnosis, prognosis estimation and treatment monitoring in a large lung cancer cohort.