Association between seasonal factors and multiple sclerosis

详细信息    查看全文

• 作者：Abdulla Watad ; Shir Azrielant ; Alessandra Soriano…
• 关键词：Multiple sclerosis ; Seasonality ; Autoimmunity ; Month of birth ; Vitamin D ; Melatonin ; Environment
• 刊名：European Journal of Epidemiology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：31
• 期：11
• 页码：1081-1089
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Epidemiology; Public Health; Infectious Diseases; Cardiology; Oncology;
• 出版者：Springer Netherlands
• ISSN：1573-7284
• 卷排序：31

文摘

Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system. MS is causing progressive and relapsing neurological disability, due to demyelination and axonal damage. The etiopathogenesis of MS is poorly understood. A number of environmental factors have been previously suggested, including: month of birth, vitamin D levels, smoking and viral infections. Previous studies assessing seasonal variation of relapses in multiple sclerosis have had conflicting results. The aim of this review is to assess the association between seasonal factors and MS, in terms of disease onset, relapses and activity.