Prenatal programming of hepatocyte nuclear factor 4α in the rat: a key mechanism in the ‘foetal origins of hyperglycaemia’?

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• 作者：M. J. Nyirenda ; S. Dean ; V. Lyons ; K. E. Chapman and J. R. Seckl
• 关键词：Foetus ; Glucocorticoids ; Hepatocyte nuclear factor 4 ; Hyperglycaemia ; Liver ; Phosphoenolpyruvate carboxykinase 2 ; Programming
• 刊名：Diabetologia
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：49
• 期：6
• 页码：1412-1420
• 全文大小：380 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Prenatal glucocorticoid exposure causes lifelong hyperglycaemia in rat offspring, associated with permanently increased hepatic phosphoenolpyruvate carboxykinase 2 (PCK2), the rate-controlling enzyme of gluconeogenesis. To elucidate the mechanisms underlying the ‘programming’ of PCK2, this study examined the effect of prenatal dexamethasone treatment on expression of transcription factors that regulate Pck2.