Synthesis, properties, and application of 4-nitrosemicarbazones

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• 作者：V. S. Glukhacheva ; S. G. Il’yasov ; G. V. Sakovich…
• 关键词：Key wordsnitrosemicarbazones ; nitrosemicarbazide ; condensation
• 刊名：Russian Chemical Bulletin
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：65
• 期：2
• 页码：550-560
• 全文大小：425 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9171
• 卷排序：65

文摘

The studies of the condensation of 4-nitrosemicarbazide (4-NSC) with various aldehydes and ketones resulted in the development of an approach to the synthesis of N-nitrosemicarbazones, promising high-energy and biologically active compounds. Subsequent treatment with amines and alkalis led to the synthesis of water-soluble salts of nitrosemicarbazones, as well as the corresponding semicarbazones. The reaction of N,N′-diisopropyl- or N,N′-di-tert-butyl-1,2-ethanediimine with 4-nitrosemicarbazide led to the synthesis of glyoxal bis(nitrosemicarbazone) derivatives. A computer-aided screening using the PASS software showed a probability of high biological activity for the compounds obtained, whereas antiarrhythmic properties of camphor nitrosemicarbazone potassium salt were confirmed in experiments in rats.