Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal
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- 作者：Wesley Wong ; Allison D. Griggs ; Rachel F. Daniels ; Stephen F. Schaffner…
- 关键词：Malaria ; Genomics ; Epidemiology ; Relatedness ; Transmission ; Coinfection ; Polygenomic infection ; Cotransmission ; Superinfection
- 刊名：Genome Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：1322KB
- 刊物主题：Human Genetics; Metabolomics; Bioinformatics; Medicine/Public Health, general; Cancer Research; Systems Biology;
- 出版者：BioMed Central
- ISSN：1756-994X
- 卷排序：9
文摘
BackgroundAs public health interventions drive parasite populations to elimination, genetic epidemiology models that incorporate population genomics can be powerful tools for evaluating the effectiveness of continued intervention. However, current genetic epidemiology models may not accurately simulate the population genetic profile of parasite populations, particularly with regard to polygenomic (multi-strain) infections. Current epidemiology models simulate polygenomic infections via superinfection (multiple mosquito bites), despite growing evidence that cotransmission (a single mosquito bite) may contribute to polygenomic infections.