The role of cGAS in innate immunity and beyond

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• 作者：Andrea Ablasser ; Muhammed F. Gulen
• 关键词：Innate immunity ; DNA sensing ; Type I interferons
• 刊名：Journal of Molecular Medicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：94
• 期：10
• 页码：1085-1093
• 全文大小：704 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Molecular Medicine
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1440
• 卷排序：94

文摘

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyond infection, accumulating evidence indicates that cGAS is also active during autoimmune diseases and controls immune responses that underlie cancer immunosurveillance. In this review, we highlight our current understanding of DNA sensing by cGAS and its involvement in human disease.