Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice

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• 作者：Wang-Jun Qin ; Yan-Ting Wang ; Peng-Mei Li ; Xiao-Xing Wang ; Jun-Xu Li…
• 关键词：Behavioral sensitization ; Context ; dependent ; Heat shock protein 70 ; Morphine ; Neurobiological sensitization
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：233
• 期：7
• 页码：1147-1155
• 全文大小：539 KB
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• 作者单位：Wang-Jun Qin (1)
  Yan-Ting Wang (2)
  Peng-Mei Li (1)
  Xiao-Xing Wang (1)
  Jun-Xu Li (3)
  Hamid R. Noori (4)
  Rick E. Bernardi (4)
  Jian-Hui Liang (5)
  Xiang-Lin Zhang (1)
  
  1. Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, China
  2. Department of Pharmacy, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China
  3. Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
  4. Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  5. Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, 100191, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Drug-induced sensitization in the mesocorticolimbic systems is thought to play an important role in certain aspects of drug addiction, including the involvement of drug-associated cues and environments in mediating drug-seeking behaviors. Our previous studies have identified the significance of heat shock protein 70 (Hsp70) in the development of a single morphine exposure-induced behavioral sensitization.