Differential modulation of methamphetamine-mediated behavioral sensitization by overexpression of Mu opioid receptors in nucleus accumbens and ventral tegmental area

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• 作者：Chi-Chung Kuo ; Hui Shen ; Brandon K. Harvey ; Seong-Jin Yu…
• 关键词：Methamphetamine ; Mu opioid receptor ; Sensitization ; AAV
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：233
• 期：4
• 页码：661-672
• 全文大小：5,345 KB
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• 作者单位：Chi-Chung Kuo (2)
  Hui Shen (2)
  Brandon K. Harvey (2)
  Seong-Jin Yu (1) (2)
  Theresa Kopajtic (1)
  Josh. J. Hinkle (2)
  Stephanos Kyrkanides (3)
  Jonathan L. Katz (2)
  Yun Wang (1) (2)
  
  2. Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, 21224, USA
  1. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan
  3. Department of Children’s Dentistry, Stony Brook University Health Science Center, Stony Brook, NY, 11794-8701, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Repeated administration of methamphetamine (Meth) induces behavioral sensitization which is characterized by a progressive increase in locomotor response after each injection. Previous studies have shown that Mu opioid receptors (MORs) can regulate Meth-mediated behavioral sensitization. However, the reported interactions are controversial; systemic activation of MORs either enhanced or suppressed Meth sensitization. It is possible that alteration of Meth sensitization after systemic administration of MOR ligands reflects the sum of distinct MOR reactions in multiple brain regions.