Data Mining in Complex Diseases Using Evolutionary Computation

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• 作者：Vanessa Aguiar ; Jose A. Seoane ; Ana Freire ; Cristian R. Munteanu
• 关键词：Association studies ; SNPs ; evolutionary computation ; genetic algorithms ; data mining
• 刊名：Lecture Notes in Computer Science
• 出版年：2009
• 出版时间：2009
• 年：2009
• 卷：5517
• 期：1
• 页码：917-924
• 全文大小：312.3 KB

文摘

A new algorithm is presented for finding genotype-phenotype association rules from data related to complex diseases. The algorithm was based on Genetic Algorithms, a technique of Evolutionary Computation. The algorithm was compared to several traditional data mining techniques and it was proved that it obtained similar classification scores but found more rules from the data generated artificially. In this paper it is assumed that several groups of SNPs have an impact on the predisposition to develop a complex disease like schizophrenia. It is expected to validate this in a short period of time on real data.