Prediction of survival in terminally ill cancer patients at the time of terminal cancer diagnosis
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- 作者：Yu Jung Kim (1) (2)
Su-Jung Kim (1) (3)
June Koo Lee (1)
Won-Suk Choi (1)
Jin Hyun Park (1) (4)
Hee Jun Kim (5)
Sung Hoon Sim (1)
Keun-Wook Lee (1) (2)
Se-Hoon Lee (1) (3)
Jee Hyun Kim (1) (2)
Dong-Wan Kim (1) (3)
Jong Seok Lee (1) (2)
Yung-Jue Bang (1) (3)
Dae Seog Heo (1) (3) - 关键词：Terminally ill ; Terminal cancer ; Prognosis ; Prediction ; Survival
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：140
- 期：9
- 页码：1567-1574
- 全文大小：402 KB
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Su-Jung Kim (1) (3)
June Koo Lee (1)
Won-Suk Choi (1)
Jin Hyun Park (1) (4)
Hee Jun Kim (5)
Sung Hoon Sim (1)
Keun-Wook Lee (1) (2)
Se-Hoon Lee (1) (3)
Jee Hyun Kim (1) (2)
Dong-Wan Kim (1) (3)
Jong Seok Lee (1) (2)
Yung-Jue Bang (1) (3)
Dae Seog Heo (1) (3)
1. Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea
2. Seoul National University Bundang Hospital, Seongnam, Republic of Korea
3. Seoul National University Hospital, Seoul, Republic of Korea
4. Seoul Municipal Boramae Hospital, Seoul, Republic of Korea
5. Chung-Ang University Hospital, Seoul, Republic of Korea - ISSN：1432-1335
文摘
Purpose We aimed to investigate the prognostic factors that can predict terminal stage survival (TSS) at the time of terminal cancer diagnosis. Methods We prospectively evaluated 141 patients immediately after the diagnosis of terminal cancer by their attending oncologists. A total of 32 factors, including performance status, clinical prediction of survival, time to terminal cancer (TTC), clinical symptoms, signs, and laboratory tests including the neutrophil–lymphocyte ratio (NLR), were analyzed. TSS was defined as the time from the diagnosis of terminal cancer to death. Results The mean age of the 141 patients studied was 58.7?years, and 53 were female (38?%). The median TSS was 1.7?months (95?% confidence interval [CI] 1.43-.97). In the univariate analyses, the TSS was significantly associated with 16 of the 32 factors tested. In the multivariate analysis, a lower Karnofsky performance status (KPS), a shorter TTC (C-reactive protein (CRP) level (?0?mg/dL) were independently associated with a poorer prognosis. A scoring system (scale, 0-) developed based on the multivariate analysis could be used to classify terminal cancer patients into better (0- points; TSS 3.9?months), intermediate (3- points; TSS 1.7?months), or worse (5- points; TSS 0.9?month, P? Conclusion The median TSS after the diagnosis of terminal cancer in advanced cancer patients was 1.7?months. The scoring system using KPS, TTC, NLR, and CRP could predict TSS in these patients.