Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK

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• 作者：Joungmin Kim ; Seong-Wook Jeong ; Hui Quan ; Cheol-Won Jeong…
• 关键词：AMPK ; CaMKK ; Curcumin ; LPS ; Macrophage
• 刊名：Journal of Anesthesia
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：30
• 期：1
• 页码：100-108
• 全文大小：969 KB
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• 作者单位：Joungmin Kim (1)
  Seong-Wook Jeong (1)
  Hui Quan (1) (2)
  Cheol-Won Jeong (1)
  Jeong-Il Choi (1)
  Hong-Beom Bae (1) (2)
  
  1. Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School and Hospital, 5 Hak dong, Gwangju, 501-746, Korea
  2. Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  
• 出版者：Springer Japan
• ISSN：1438-8359

文摘

Purpose Curcumin, a biphenolic compound extracted from turmeric (Curcuma longa), possesses potent anti-inflammatory activity. The present study investigated whether curcumin could increase 5′ adenosine monophosphate-activated protein kinase (AMPK) activity in macrophages and modulate the severity of lipopolysaccharide (LPS)-induced acute lung injury.