Effectiveness of antioxidant and membrane oxygenator in acute respiratory distress syndrome by endotoxin

详细信息    查看全文

• 作者：Seong-Jong Kim (1)
  Kyung-Hwa Kim (2)
  Shang-Jin Kim (3)
  Hyung-Sub Kang (3)
  Jin-Shang Kim (3)
  Min-Ho Kim (4)
  Jung-Ku Jo (4)
  Jong-Beum Choi (4)
  Yeong-Seok Yang (5)
  Sung-Jun Kang (6)
  Gi-Beum Kim (3)
  
• 关键词：ARDS ; Membrane Oxygenator ; Endotoxin ; Antioxidant ; Dexamethasone
• 刊名：Korean Journal of Chemical Engineering
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：29
• 期：11
• 页码：1597-1603
• 全文大小：1237KB
• 参考文献：1. D. G. Ashbaugh, D. B. Bigelow, T. L. Petty and B. E. Levine, / Lancet, 2(3), 319 (1967). CrossRef
  2. T. L. Petty and D. G. Ashbaugh, / Chest, 60, 233 (1971). CrossRef
  3. J. Villar and A. S. Slutsky, / Am. Reu. Respir. Dis., 40, 814 (1989).
  4. M. E. Hanley and J. E. Repine, / Sem. Respir. Crit. Care. Med., 15, 260 (1994). CrossRef
  5. G. D. Pearson and B. E. Short, / J. Intens. Care. Med., 2, 116 (1986). CrossRef
  6. N. N. Finderv, A. J. Tierney, A. Hayashi, A. Peliowski and P. C. Etches, / J. Can. Med. Assoc., 146, 501 (1992).
  7. F. L. Fazzalari, R. H. Bartlett, M. R. Bonnell and J. P. Montoya, / J. Artif. Organs, 18, 801 (1994). CrossRef
  8. S. N. Vaslcf, L. F. Moekros and R.W. Anderson, / Trans. Am. Soc. Artif. Intern. Organs, 35, 660 (1989). CrossRef
  9. W. J. Federspiel, T. Hewitt, M. S. Hout, F. R. Walters, L.W. Lund, P. J. Sawzik, G. Reeder, H. S. Borovetz and B.G. Hattler, / ASAIO, 42, 435 (1996). CrossRef
  10. W. J. Federspiel, J. L. William and B.G. Hattler, / AIChE J., 42, 2094 (1996). CrossRef
  11. W. J. Fedespiel, M. S. Hout, T. J. Hewitt, L.W. Lund, S. A. Heinrich, P. Liwak, F. R. Walters, G. D. Reeder, H. S. Borovetz and B.G. Hattler, / ASAIO, 43, 725 (1997). CrossRef
  12. G. B. Kim, S. J. Kim, M. H. Kim, C. U. Hong and H. S. Kang, / J. Membr. Sci., 326, 130 (2009). CrossRef
  13. G. B. Kim, S. J. Kim, C. U. Hong, Y. C. Lee and M. H. Kim, / J. Biomed. Eng. Res., 27, 143 (2006).
  14. G. B. Kim, C. U. Hong and T. K. Kwon, / J. Artifi. Organs, 9, 34 (2006). CrossRef
  15. G.B. Kim, C.U. Hong and T. K. Kwon, / Jpn. J. Appl. Phys., 45, 3811 (2006). CrossRef
  16. G.B. Kim, S. J. Kim, C.U. Hong, T. K. Kwon and M.G. Kim, / Korea J. Chem. Eng., 22, 521 (2005). CrossRef
  17. P.M. Dorinsky and J. E. Gadek, / Clin. Chest. Med., 11, 581 (1990).
  18. S. J. Weiss, / N. Eng. J. Med., 321, 327 (1989). CrossRef
  19. K. E. Stephens, A. Ishizaka, J.W. Larrick and T. A. Raffin, / Am. Rev. Respir. Dis., 137, 1364 (1988).
  20. G.R. Bernard, A. Artlgas, K. L. Briqham, J. Carlet, K. Falke, L. Hudson, M. Lamy, J. R. Leqall, A. Morris and R. Spraqq, / Am. J. Respir. Crit. Care. Med., 149, 818 (1994).
  21. D. A. Partrick, E. E. Moore, C. C. Silliman, C. C. Barnett and F. A. Kuypers, / Crit. Care. Med., 29, 42 (2001). CrossRef
  22. T. Nagase, N. Uozumi, S. Ishii, K. Kume, T. Izumi, Y. Ouchi and T. Shimizu, / Nature Immunol., 1, 13 (2000). CrossRef
  23. L. P. Vernon and J. B. Bell, / Pharmac. Ther., 54, 269 (1992). CrossRef
  24. R. J. Elin, E. N. Hristova, S. A. Cecco, J. E. Niemela and N. N. Rehak, / Scand. J. Clin. Lab. Invest., 56, 203 (1999). CrossRef
  25. S. H. Jeon, M.Y. Lee, Md. M. Rahman, S. J. Kim, G. B. Kim, S.Y. Park, C. U. Hong, S. Z. Kim, J. S. Kim and H. S. Kang, / Pulm. Pharnacol. Ther., 22. 562 (2009). CrossRef
  26. S. H. Jeon, H.M. Park, S. J. Kim, N.Y. Lee, G.B. Kim, Md. M. Rahman, J.N. Woo, I. S. Kim, J. S. Kim and H. S. Kang, / Hum. Exp. Toxicol., 29, 627 (2009). CrossRef
  
• 作者单位：Seong-Jong Kim (1)
  Kyung-Hwa Kim (2)
  Shang-Jin Kim (3)
  Hyung-Sub Kang (3)
  Jin-Shang Kim (3)
  Min-Ho Kim (4)
  Jung-Ku Jo (4)
  Jong-Beum Choi (4)
  Yeong-Seok Yang (5)
  Sung-Jun Kang (6)
  Gi-Beum Kim (3)
  
  1. Division of Chemical Engineering, Chonbuk National University, 664-14, 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk, 561-756, Korea
  2. Research Institute of Clinical Medicine, Chonbuk National University, Chonbuk National University Hospital, 664-14, 1Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk, 561-756, Korea
  3. Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University, 664-14, 1Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk, 561-756, Korea
  4. Chonbuk National University Medical Schools, 664-14, 1Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk, 561-756, Korea
  5. Division of Pharmaceutical Engineering, Woosuk University, 443, Samnye-ro, Samnye-eup, Wanju-gun, Jeonbuk, 565-701, Korea
  6. Division of Mechanical System Engineering, Chonbuk National University, 664-14, 1Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk, 561-756, Korea
  
• ISSN：1975-7220

文摘

This study evaluated the effectiveness of antioxidants in animal models with damaged lungs such as inflammatory mediator-induced acute respiratory distress syndrome (ARDS) and established an ARDS therapy technique by suppressing active oxygen with membrane oxygenator. When inflammatory mediator that has an endotoxin, such as LPS, was injected directly into the airway, inflammatory pulmonary edema developed in the lung, and could induce ARDS. To treat such endotoxin-induced ARDS, the antioxidants such as taurine and dexamethasone were injected and their antioxidant effects were evaluated. They turned the blood pH to the normal condition, increased blood hemoglobin and hemocrit concentration and oxygen partial pressure (PO2), and improved survival. When a membrane oxygenator was used alone on the animal models with ARDS, similar antioxidant effects were identified. When a membrane oxygenator and antioxidants were used simultaneously, synergistic antioxidant effects were revealed. Therefore, the simultaneous use of antioxidants and membrane oxygenator is more effective than the use of either of them in treating the animal models with ARDS. This result indicates that bilateral use of antioxidants and membrane oxygenator may be useful as a potential therapy technique for the treatment of acute respiratory distress syndrome.