Maligne hypertherme Syndrome auf der Intensivstation

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• 作者：Dr. W. Grander
• 刊名：Medizinische Klinik
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：111
• 期：5
• 页码：407-416
• 全文大小：254 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Medicine/Public Health, general
  
• 出版者：Urban & Vogel
• ISSN：1615-6722
• 卷排序：111

文摘

Malignant hyperthermia is a life-threatening disease caused by derangement of the autonomic nerve system and hypermetabolism of the peripheral musculature. Commonly body core temperatures of more than 40 °C will be found in this disease which is caused mostly by psychopharmacological drugs like antidepressants, neuroleptics but also antibiotics, pain killers, anti-Parkinson drugs, and volatile anesthetics. The inducers of malignant hyperthermia interact with postsynaptic receptors (serotonin, anticholinergics) or muscular intracellular structures responsible for calcium utilization (volatile anesthetics, succinylcholine). Rarely malignant hyperthermia is a consequence of mental stress or vigorous exercise and or heat. Malignant hyperthermic syndromes lead to a severe dysbalance of the autonomic nerve system accompanied by rhabdomyolysis, disseminated intravascular coagulopathy, and finally multi-organ failure. Accordingly, medical management is primarily directed to stabilize vital functions, withdrawal of the causing drug, and if possible antagonizing toxic substances. The leading symptom hyperthermia needs to be treated physically with available cooling systems.KeywordsFeverMalignant hyperthermiaNeuroleptic malignant syndromeAnestheticsRhabdomyolysis