Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells
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- 作者：Hari Jang ; Jin Woo Lee ; Chul Lee ; Qinghao Jin…
- 关键词：Tussilago farfara ; Asteraceae ; Oplopane ; type sesquiterpenoid ; Nitric oxide production inhibitor
- 刊名：Archives of Pharmacal Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：39
- 期：1
- 页码：127-132
- 全文大小：643 KB
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Jin Woo Lee (1)
Chul Lee (1)
Qinghao Jin (1)
Jeong Yeon Choi (1)
Dongho Lee (2)
Sang Bae Han (1)
Youngsoo Kim (1)
Jin Tae Hong (1)
Mi Kyeong Lee (1)
Bang Yeon Hwang (1)
1. College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea
2. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea - 刊物主题：Pharmacy; Pharmacology/Toxicology;
- 出版者：Springer Netherlands
- ISSN：1976-3786
文摘
A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3–20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8–12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5–28.5 μM. Keywords Tussilago farfara Asteraceae Oplopane-type sesquiterpenoid Nitric oxide production inhibitor