BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy

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• 作者：Alexandra Kleimann ; Alexandra Kotsiari ; Wolfgang Sperling…
• 关键词：Brain ; derived neurotrophic factor ; Electroconvulsive therapy ; Treatment ; resistant depression ; DNA methylation ; Promoter
• 刊名：Journal of Neural Transmission
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：122
• 期：6
• 页码：925-928
• 全文大小：404 KB
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• 作者单位：Alexandra Kleimann (1)
  Alexandra Kotsiari (1)
  Wolfgang Sperling (2)
  Michael Gr?schl (3)
  Annemarie Heberlein (1)
  Kai G. Kahl (1)
  Thomas Hillemacher (1)
  Stefan Bleich (1)
  Johannes Kornhuber (2)
  Helge Frieling (1)
  
  1. Laboratory for Molecular Neuroscience, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School (MHH), Carl-Neubergstr. 1, 30625, Hannover, Germany
  2. Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Maximiliansplatz 2, 91054, Erlangen, Germany
  3. Bioanalytical Laboratory, Celerion Switzerland AG, Allmendstr. 32, 8320, Fehraltorf, Switzerland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463

文摘

We examined potential changes in brain-derived neurotrophic factor (BDNF) serum levels and promoter methylation of the BDNF gene in 11 patients with treatment-resistant major depressive disorder during a series of electroconvulsive therapy (ECT). Blood samples were taken before, 1 and 24?h after ECT treatment sessions 1, 4, 7 and 10. Patients remitting under ECT had significantly lower mean promoter methylation rates, especially concerning the exon I promoter, compared to non-remitters (both p?<?0.002). These findings may point to a depression subtype in which ECT is particularly beneficial.