Glutathione-responsive gemini polymeric micelles as controlled drug carriers

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• 作者：Hyun-Chul Kim (1)
  Eunjoo Kim (1)
  Sang Won Jeong (1)
  Se Guen Lee (1)
  Sung Jun Lee (1)
  Seung Woo Lee (2)
  
  1. Nano & Bio Research Division ; Daegu Gyeongbuk Institute of Science and Technology (DGIST) ; Daegu ; 711-873 ; Korea
  2. School of Chemical Engineering ; Yeungnam University ; Gyeongbuk ; 712-749 ; Korea
  
• 关键词：gemini surfactants ; drug delivery system ; polypeptide ; disulfide ; thiol exchange ; stimuli ; sensitive polymers
• 刊名：Macromolecular Research
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：23
• 期：2
• 页码：196-204
• 全文大小：749 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Physical Chemistry
  Polymer Sciences
  Characterization and Evaluation of Materials
  Soft and Granular Matter, Complex Fluids and Microfluidics
  Nanochemistry
  Nanotec
  
• 出版者：The Polymer Society of Korea, co-published with Springer
• ISSN：2092-7673

文摘

Gemini poly(ethylene glycol)-cystine-poly(s-butyl cysteine) ((PEG)2-Cyt-(PBC)2) with a cystine disulfide bond as a spacer was prepared via oxidation of the cysteine group of monomeric poly(ethylene glycol)-cysteine-poly(s-butyl cysteine) (PEG-Cys-PBC) in solution, which is specifically cleavable in intracellular compartments. Due to its amphiphilic nature, (PEG)2-Cyt-(PBC)2 formed micelles under aqueous conditions; the average diameter of the micelles was 26.9 nm. The critical micelle concentration (CMC) of the polymer was 15.8 mg/L. The loading content of the chosen model drug, indomethacine (IMC), was much higher for gemini micelles than that for monomeric micelles. The (PEG)2-Cyt-(PBC)2 micelles released 75% of the loaded IMC within 72 h under 10 mM glutathione (GSH), whereas 36% of the loaded IMC was released from the micelles in the absence of GSH. An in vitro cytotoxicity experiment revealed that PTX-loaded gemini micelles showed toxicity to A549 cells with increasing GSH concentrations. Microscopic observation of gemini micelles demonstrated that the micelles containing a disulfide bond could effectively deliver the drug into A549 cells. These results suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers.