Suvanine analogs from a Coscinoderma sp. marine sponge and their cytotoxicities against human cancer cell lines

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• 作者：Jeong-Woo Lee ; Hyi-Seung Lee ; Jongheon Shin…
• 关键词：Marine sponge ; Coscinoderma ; Sulfated sesterterpenoid ; Suvanine ; Cytotoxicity ; Human cancer cell line
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：38
• 期：6
• 页码：1005-1010
• 全文大小：419 KB
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• 作者单位：Jeong-Woo Lee (1)
  Hyi-Seung Lee (1)
  Jongheon Shin (2)
  Jong Soon Kang (3)
  Jieun Yun (3)
  Hee Jae Shin (1)
  Jong Seok Lee (1)
  Yeon-Ju Lee (1)
  
  1. Marine Natural Product Chemisty Laboratory, Korea Institute of Ocean Science and Technology, Ansan, 426-744, Republic of Korea
  2. Natural Product Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul, 151-742, Republic of Korea
  3. Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, 323-833, Republic of Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Nine suvanine analogs including suvanine phenethylammonium salt and two new compounds were isolated from the marine sponge Coscinoderma sp., collected from Chuuk State, Federated States of Micronesia. The structures of the new compounds were elucidated by 2D NMR and HRMS analyses. Suvanine and a new analog exhibited weak but selective cytotoxicity against colon (HCT-15), lung (NCI-H23), stomach (NUGC-3), and prostate (PC-3) cancer cell lines.