Cytotoxic Petrosiacetylenes from the Marine Sponge Petrosia sp.

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• 作者：Yeon-Ju Lee (1)
  Su-Jung Yoo (1)
  Jong Soon Kang (2)
  Jieun Yun (2)
  Hee Jae Shin (1)
  Jong Seok Lee (1)
  Hyi-Seung Lee (1)
  
• 关键词：Sponge ; Petrosia ; Polyacetylenic alcohol ; Petrosiacetylene ; Cytotoxicity
• 刊名：Lipids
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：48
• 期：1
• 页码：87-91
• 全文大小：275KB
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• 作者单位：Yeon-Ju Lee (1)
  Su-Jung Yoo (1)
  Jong Soon Kang (2)
  Jieun Yun (2)
  Hee Jae Shin (1)
  Jong Seok Lee (1)
  Hyi-Seung Lee (1)
  
  1. Korea Institute of Ocean Science and Technology, Ansan, 426-744, Republic of Korea
  2. Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, 363-883, Republic of Korea
  
• ISSN：1558-9307

文摘

A novel petrosiacetylene analog (petrosiacetylene E) has been isolated from the Korean marine sponge Petrosia sp., along with petrosiacetylene A, B and C. Their structures were elucidated on the basis of spectroscopic methods and the stereochemistry of the new compound was determined by using the modified Mosher’s method. Petrosiacetylene E showed higher cytotoxicity against five human cancer cell lines than petrosiacetylene A and B, presumably due to the additional hydroxy group located at C-16.