Noncytopathic bovine viral diarrhea virus 2 impairs virus control in a mouse model

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• 作者：Giyong Seong ; Jin-Sol Lee ; Kyung-Hyun Lee ; Seung-Uk Shin…
• 刊名：Archives of Virology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：161
• 期：2
• 页码：395-403
• 全文大小：5,826 KB
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• 作者单位：Giyong Seong (1)
  Jin-Sol Lee (1)
  Kyung-Hyun Lee (2)
  Seung-Uk Shin (1)
  Ji Young Yoon (3)
  Kyoung-Seong Choi (1)
  
  1. College of Ecology and Environmental Science, Kyungpook National University, Sangju, 742-711, Republic of Korea
  2. Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Anyang, 430-824, Republic of Korea
  3. Jeonju Biomaterials Institute, Jeonju, 561-360, Republic of Korea
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798

文摘

Bovine viral diarrhea virus (BVDV) is an economically important pathogen that causes development of mild to severe clinical signs in wild and domesticated ruminants. We previously showed that mice could be infected by BVDV. In the present study, we infected mice intraperitoneally with non-cytopathic (ncp) BVDV1 or ncp BVDV2, harvested the blood and organs of the infected mice at days 4, 7, 10 and 14 postinfection (pi), and performed immunohistochemical analyses to confirm BVDV infection. Viral antigens were detected in the spleens of all infected mice from days 4 through 14 and were also found in the mesenteric lymph nodes, gut-associated lymphoid tissue (GALT), heart, kidney, intestine, and bronchus-associated lymphoid tissue (BALT) of some infected mice. In ncp BVDV2-infected mice, flow cytometric analysis revealed markedly fewer CD4+ and CD8+ T lymphocytes and lower expression of costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and major histocompatibility complex (MHC) class II (I-A/I-E) than those in ncp BVDV1-infected mice. Production of the cytokines interleukin (IL)-6 and monocyte chemotactic protein (MCP)-1 was higher in the plasma of ncp BVDV2-infected mice than that in that of ncp BVDV1-infected mice. Our results demonstrate that ncp BVDV1 and ncp BVDV2 interact differently with the host innate immune response in vivo. These findings highlight an important distinction between ncp BVDV1 and ncp BVDV2 and suggest that ncp BVDV2 impairs the host’s ability to control the infection and enhances virus dissemination. G. Seong, J.-S. Lee and K.-H. Lee contributed equally to this work.