Transfer rates of toxic metals during decoction preparation from hebal medicines and safety evaluation of the final decoction products

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• 作者：Dong-Gyu Kim (1) (2)
  Sung-Deuk Lee (1)
  In-Sil Yu (1)
  Kweon Jung (1)
  Seung-Kook Park (2)
  
  1. Seoul Metropolitan Government Research Institute of Public Health and Environment ; Gwacheon ; Gyeonggi ; 427070 ; Korea
  2. Department of Food Science and Biotechnology ; Institute of Life Science and Resources ; Kyung Hee University ; Yongin ; Gyeonggi ; 446-701 ; Korea
  
• 关键词：herbal medicine ; decoction ; toxic metal ; transfer rate ; risk assessment
• 刊名：Food Science and Biotechnology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：24
• 期：2
• 页码：757-763
• 全文大小：177 KB
• 参考文献：1. Lee, S, Park, Y (2012) Toxicology for herbal medicine I. KSI Publishers, Paju, Korea
  2. Liang, YZ, Xie, P, Chan, K (2004) Quality control of herbal medicines. J. Chromatogr. B 812: pp. 53-70 CrossRef
  3. Choi, DW, Kim, JH, Cho, SY, Kim, DH, Chang, SY (2002) Regulation and quality control of herbal drugs in Korea. Toxicology 181鈥?82: pp. 581-586 CrossRef
  WHO guidelines on good agricultural and collection practices (GACP) for medicinal Plants. WHO Press, Geneva, Switzerland
  4. Mukherjee, P (2012) GMP for botanicals, regulatory, and quality issues on phytomedicines. Business Horizon, New Delhi, India
  5. Kim, D, Kim, K, Lee, S, Jo, S, Lee, H, Jung, S, Jung, K, Park, S (2014) Distribution of foreign mineral materials and heavy metals contained in herbal medicines, and effect of washing. Korean J. Pharmacogn. 45: pp. 41-47
  The Korean herbal pharmacopoeia (KHP).
  The Korean pharmacopoeia eleventh edition (KP 11).
  Risk assessment in the federal government: Managing the process. National Academy Press, Washington DC, USA
  IARC monographs on the evaluation of carcinogencid risks to humans.
  Integrated risk information system. Cadmium. (CASRN 7440-43-9).
  6. Sohn, J, Lee, C (2007) The risk assessment of hazard chemical in environment. J. Korean Soc. Environ. Eng. 29: pp. 477-488
  Integrated risk information system (IRIS).
  7. Lee, SD, Park, HM, Lee, JC, Kook, YB (2003) Concentration of metal in herbal drugs-in crude, remnant after boiling and decoction of herbal drugs. J. Korean Med. 24: pp. 59-65
  8. Lee, SH, Wee, IJ, Park, CH (2012) Reduction of toxic metals in traditional asian herbs by decoction preparation. J. Bioprocess Biotech. 2: pp. 122
  9. Kim, D, Kim, K, Lee, S, Jung, K, Park, S (2014) Monitoring of total ash, acid-insoluble ash and heavy metals content contained in herbal medicines classified by parts used. Anal. Sci. Technol. 27: pp. 114-120 CrossRef
  Report of the Joint FAO/WHO consultation of food consumption and exposure assessment of chemicals. WHO Press, Geneva, Switzerland
  Guidebook of Risk Assessment (NO:11-1470550-000179-14). KFDA Press, Seoul, Korea
  Integrated risk information system.
  Integrated risk information system.
  Integrated risk information system.
  Human health risk assessment.
  Regional screening levels (Formerly PRGs) Screening levels for chemical contaminants (2010) Region III risk-based concentration table.
  Guidebook of risk assessment in soil contamination.
  10. Lim, H, Lee, J, Chon, H, Sager, M (2008) Heavy metal contamination and health risk assessment in the vicinity of the abandoned Songcheon Au-Ag mine in Korea. J. Geochem. Explor. 96: pp. 223-230 CrossRef
  11. Park, H, Choi, K, Jung, J, Lee, SD (2006) Mental exposure through consumption of heavy medicine, and estimation of health risk among Korean population. J. Environ. Health Sci. 32: pp. 186-191
  12. Hwang, K (2012) Monitoring of heavy metals in herbal medicines circulating in Seoul and risk assessment by taking decoction of frequent prescriptions in Seoul. PhD thesis, Dankook University, Cheonan, Korea
  13. Lee, S, Jung, J, Choi, K, Lee, J, Park, H, Shin, H (2010) Risk analysis and estimating consumption of heavy metal from intake of oriental medicines. J. Environ. Health Sci. 36: pp. 14-19
  Regional screening levels.
  14. Kim, N, Sim, S, Ryu, J, Kim, J, Hong, N (1996) Studies on contents and elution of metals from crude drugs. J. Kyung Hee Univ. Med. Cent. 12: pp. 158-166
  15. Jung, S, Kang, S, Han, C, Kim, S, Ko, S, Kim, Y, Kim, Y, Kim, B, Choi, B (2010) Survey of heavy metal contents and intake rates after decoction in herbal medicines classified by parts. J. Fd. Hyg. Safety 25: pp. 402-409
  16. Yim, O, Han, E, Chung, J, Park, K, Kang, I, Kang, S, Kim, Y (2009) The monitoring of some heavy metals in oriental herbal medicines and their intake rates. Anal. Sci. Technol. 22: pp. 128-135
  17. Seo, C, Huang, D, Lee, J, Ha, H, Chun, J, Um, Y, Jang, S, Shin, H (2008) Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. Korean J. Herbology 23: pp. 51-58
  Korean food standard codex: fruits and vegetables beverages (5-18-1).
  Short information documents for decision makers.
  18. Castorina, R, Woodruff, T (2003) Assessment of potential risk levels associated U.S. environmental protection agency reference values. Environ. Health Persp. 110: pp. 1318-1325 CrossRef
  19. Lee, S, Lee, Y, Kim, M, Park, S, Kim, Y, Chae, Y (2012) The content and risk assessment of heavy metals in herbal pills. J. Fd. Hyg. Safety 27: pp. 375-387 CrossRef
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

Transfer rates of toxic metals during herbal decoction preparation were investigated using risk assessment tools. Decoction samples were analyzed using Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) and a mercury analyzer after microwave digestion. The average decoction transfer rate (%) for each toxic metal after boiling was 10.5 for As, 4.3 for Pb, 4.1 for Cd, and 2.7 for Hg. A risk assessment of toxic metals in decoctions was performed based on the percentage provisional tolerable weekly intake (PTWI) values for a mean value scenario and a 95th percentile value scenario. Samples were collected of 68 decoctions representing 8 types frequently prescribed by oriental medicine clinics in Seoul, Korea. Both scenarios demonstrated low PTWI values. All decoction samples were safe according to risk assessment results.