The respiratory microbiome in bronchial mucosa and secretions from severe IgE-mediated asthma patients
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- 作者：Laura Millares ; Guadalupe Bermudo ; Vicente Pérez-Brocal…
- 关键词：Microbiome ; Asthma ; Biopsy ; Bronchial aspirate
- 刊名：BMC Microbiology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：933KB
- 刊物主题：Microbiology; Biological Microscopy; Mycology; Parasitology; Virology; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2180
- 卷排序：17
文摘
BackgroundThe bronchial microbiome in chronic lung diseases presents an abnormal pattern, but its microbial composition and regional differences in severe asthma have not been sufficiently addressed. The aim of the study was to describe the bacterial community in bronchial mucosa and secretions of patients with severe chronic asthma chronically treated with corticosteroids in addition to usual care according to Global Initiative for Asthma. Bacterial community composition was obtained by 16S rRNA gene amplification and sequencing, and functional capabilities through PICRUSt.