Association between increased blood interleukin-6 levels on emergency department arrival and prolonged length of intensive care unit stay for blunt trauma
参考文献:1.Lord JM, Midwinter MJ, Chen YF, Belli A, Brohi K, Kovacs EJ, et al. The systemic immune response to trauma: an overview of pathophysiology and treatment. Lancet. 2014;384:1455–65.CrossRef PubMed 2.Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464:104–7.PubMedCentral CrossRef PubMed 3.Laupland KB, Kirkpatrick AW, Kortbeek JB, Zuege DJ. Long-term mortality outcome associated with prolonged admission to the ICU. Chest. 2006;129:954–9.CrossRef PubMed 4.Ulvik A, Kvale R, Wentzel-Larsen T, Flaatten H. Multiple organ failure after trauma affects even long-term survival and functional status. Crit Care. 2007;11:R95.PubMedCentral CrossRef PubMed 5.Durham RM, Moran JJ, Mazuski JE, Shapiro MJ, Baue AE, Flint LM. Multiple organ failure in trauma patients. J Trauma. 2003;55:608–16.CrossRef PubMed 6.Dewar DC, Tarrant SM, King KL, Balogh ZJ. Changes in the epidemiology and prediction of multiple-organ failure after injury. J Trauma Acute Care Surg. 2013;74:774–9.CrossRef PubMed 7.Ciesla DJ, Moore EE, Johnson JL, Sauaia A, Cothren CC, Moore JB, et al. Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. Arch Surg. 2004;139:590–4. discussion 4–5.CrossRef PubMed 8.Lee CC, Marill KA, Carter WA, Crupi RS. A current concept of trauma-induced multiorgan failure. Ann Emerg Med. 2001;38:170–6.CrossRef PubMed 9.Gebhard F, Pfetsch H, Steinbach G, Strecker W, Kinzl L, Bruckner UB. Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg. 2000;135:291–5.CrossRef PubMed 10.Jastrow 3rd KM, Gonzalez EA, McGuire MF, Suliburk JW, Kozar RA, Iyengar S, et al. Early cytokine production risk stratifies trauma patients for multiple organ failure. J Am Coll Surg. 2009;209:320–31.CrossRef PubMed 11.Cuschieri J, Bulger E, Schaeffer V, Sakr S, Nathens AB, Hennessy L, et al. Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure. Shock (Augusta, Ga). 2010;34:346–51.CrossRef 12.Andruszkow H, Fischer J, Sasse M, Brunnemer U, Andruszkow JH, Gansslen A, et al. Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children. Scand J Trauma Resusc Emerg Med. 2014;22:16.PubMedCentral CrossRef PubMed 13.Frink M, van Griensven M, Kobbe P, Brin T, Zeckey C, Vaske B, et al. IL-6 predicts organ dysfunction and mortality in patients with multiple injuries. Scand J Trauma Resusc Emerg Med. 2009;17:49.PubMedCentral CrossRef PubMed 14.Stensballe J, Christiansen M, Tonnesen E, Espersen K, Lippert FK, Rasmussen LS. The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality. Acta Anaesthesiol Scand. 2009;53:515–21.CrossRef PubMed 15.Pfafflin A, Schleicher E. Inflammation markers in point-of-care testing (POCT). Anal Bioanal Chem. 2009;393:1473–80.CrossRef PubMed 16.Boyd CR, Tolson MA, Copes WS. Evaluating trauma care: the TRISS method. Trauma Score and the Injury Severity Score. J Trauma. 1987;27:370–8.CrossRef PubMed 17.Lipsett PA, Swoboda SM, Dickerson J, Ylitalo M, Gordon T, Breslow M, et al. Survival and functional outcome after prolonged intensive care unit stay. Ann Surg. 2000;231:262–8.PubMedCentral CrossRef PubMed 18.Lin FC, Tsai SC, Li RY, Chen HC, Tung YW, Chou MC. Factors associated with intensive care unit admission in patients with traumatic thoracic injury. J Int Med Res. 2013;41:1310–7.CrossRef PubMed 19.Baker SP, O'Neill B, Haddon Jr W, Long WB. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14:187–96.CrossRef PubMed 20.Champion HR, Sacco WJ, Carnazzo AJ, Copes W, Fouty WJ. Trauma score. Crit Care Med. 1981;9:672–6.CrossRef PubMed 21.Newgard CD, Schmicker RH, Hedges JR, Trickett JP, Davis DP, Bulger EM, et al. Emergency medical services intervals and survival in trauma: assessment of the "golden hour" in a North American prospective cohort. Ann Emerg Med. 2010;55:235–46. e4.PubMedCentral CrossRef PubMed 22.Hayakata T, Shiozaki T, Tasaki O, Ikegawa H, Inoue Y, Toshiyuki F, et al. Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock (Augusta, Ga). 2004;22:102–7.CrossRef 23.Maier B, Schwerdtfeger K, Mautes A, Holanda M, Muller M, Steudel WI, et al. Differential release of interleukines 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury. Shock (Augusta, Ga). 2001;15:421–6.CrossRef 24.Hergenroeder GW, Moore AN, McCoy Jr JP, Samsel L, Ward 3rd NH, Clifton GL, et al. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury. J Neuroinflammation. 2010;7:19.PubMedCentral CrossRef PubMed 25.Strecker W, Gebhard F, Perl M, Rager J, Buttenschon K, Kinzl L, et al. Biochemical characterization of individual injury pattern and injury severity. Injury. 2003;34:879–87.CrossRef PubMed
1. Senshu Trauma and Critical Care Center, 2-23 Rinku Orai Kita, Osaka, 598-8577, Japan 2. Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo, Chiba, 260-8677, Japan
刊物主题:Emergency Medicine; Traumatic Surgery;
出版者:BioMed Central
ISSN:1749-7922
文摘
Background Systemic immune response to injury plays a key role in the pathophysiological mechanism of blunt trauma. We tested the hypothesis that increased blood interleukin-6 (IL-6) levels of blunt trauma patients on emergency department (ED) arrival are associated with poor clinical outcomes, and investigated the utility of rapid measurement of the blood IL-6 level.