Efficacy of Cholestyramine Ointment in Reduction of Postoperative Pain and Pain During Defecation After Open Hemorrhoidectomy: Results of a Prospective, Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial: Reply

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• 作者：Shahram Ala (1)
  
• 刊名：World Journal of Surgery
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：37
• 期：8
• 页码：2009-2010
• 全文大小：104KB
• 参考文献：1. Ala S, Eshghi F, Enayatifard R et al (2013) Efficacy of cholestyramine ointment in reduction of postoperative pain and pain during defecation after open hemorrhoidectomy: results of a prospective, single-center, randomized, double-blind, placebo-controlled trial. World J Surg 37:657鈥?62. doi:10.1007/s00268-012-1895-3 CrossRef
  2. Ala S, Saeedi M, Eshghi F et al (2013) Efficacy of 10聽% sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy: a prospective, double-blind, randomized, placebo-controlled trial. World J Surg 37:233鈥?38. doi:10.1007/s00268-012-1805-8 CrossRef
  3. Ala S, Saeedi M, Eshghi F et al (2008) Topical metronidazole can reduce pain after surgery and pain on defecation in postoperative hemorrhoidectomy. Dis Colon Rectum 51:235鈥?38 CrossRef
  4. Nicholson T, Armstrong D (2004) Topical metronidazole (10聽%) decreases posthemorrhoidectomy pain and improves healing. Dis Colon Rectum 47:711鈥?16 CrossRef
  5. Siddiqui MRS, Abraham-Igwe C, Shangumanandan A et al (2011) A literature review on the role of chemical sphincterotomy after Milligan鈥揗organ hemorrhoidectomy. Int J Colorectal Dis 26:685鈥?92 CrossRef
  6. Kisli E, Baser M, G眉ler O et al (2005) Comparison of the analgesic effect of betamethasone and diclofenac potassium in the management of postoperative haemorrhoidectomy pain. Acta Chir Belg 105:388鈥?91
  7. Goldstein ET, Williamson PR, Larach SW (1993) Subcutaneous morphine pump for postoperative hemorrhoidectomy pain management. Dis Colon Rectum 36:439鈥?46 CrossRef
  8. Bronaut G, Pouzeratte Y, Mann C et al (2003) Posterior perineal block with ropivacaine 0.75聽% for pain control during and after hemorrhoidectomy. Reg Anesth Pain Med 28:228鈥?32
  9. Karanlik H, Akturk R, Camlica H et al (2009) The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind placebo controlled study. Dis Colon Rectum 52:280鈥?85 CrossRef
  10. Ratnasingham K, Uzzaman MM, Andreani SM et al (2010) Metaanalysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing. Int J Surg 8:606鈥?11 CrossRef
  11. Silverman R, Bendick PJ, Wasvary H (2005) A randomized, prospective, double-blind, placebo-controlled trial of the effect of a calcium channel blocker ointment on pain after hemorrhoidectomy. Dis Colon Rectum 48:1913鈥?916 CrossRef
  12. Chauhan A, Tiwari S, Mishra VK et al (2009) Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief: a prospective randomized trial. J Postgrad Med 55:22鈥?6 CrossRef
  13. Perrotti P, Dominici P, Grossi E et al (2010) Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized double-blind study. Can J Surg 53:17鈥?4
  14. Davies J, Duffy D, Boyt N et al (2003) Botulinum toxin (Botox) reduces pain after hemorrhoidectomy: results of a double-blind, randomized study. Dis Colon Rectum 46:1097鈥?102 CrossRef
  15. Patti R, Almasio PL, Arcara M et al (2006) Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial. Dis Colon Rectum 49:1741鈥?748 CrossRef
  16. Szabo S, Hollander D (1989) Pathways of gastrointestinal protection and repair: mechanisms of action of sucralfate. Am J Med 86(Suppl 6A):23鈥?1 CrossRef
  17. Rees WDW (1991) Mechanisms of gastroduodenal protection by sucralfate. Am J Med 91(Suppl 2A):58S鈥?3S CrossRef
  18. Folkman J, Szabo S, Shing Y (1990) Sucralfate affinity for fibroblast growth factor. J Cell Biol 111:223A
  19. Szabo S, Vattay P, Scarbrough E et al (1991) Role of vascular factors, including angiogenesis, in the mechanisms of action of sucralfate. Am J Med 91(Suppl 2A):158S鈥?60S CrossRef
  20. Hayashi AH, Lau HYC, Gillis DA (1991) Topical sucralfate: effective therapy for the management of resistant peristomal and perineal excoriation. J Pediatr Surg 26:1279鈥?281 CrossRef
  
• 作者单位：Shahram Ala (1)
  
  1. Department of Clinical Pharmacy, Mazandaran University of Medical Sciences, 48175-866, Sari, Iran
  

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